Journal article
Cardiovascular responses to carbon dioxide before and after beta-adrenergic blockade
Journal of applied physiology (1985), Vol.22(2), pp.223-226
02/1967
DOI: 10.1152/jappl.1967.22.2.223
PMID: 6017887
Abstract
Measurements of circulatory responses to breathing IO~]~ CO? were made on 30 dogs anesthetized with chloralose and urethan. Breathing CO2 for IO min caused peripheral vasoconstriction, increased arterial pressure, and decreased cardiac output in the first group of 7 dogs. Observations were made in a second group of 14 dogs after treatment with hexamethonium to inhibit cardiovascular reflexes. In these, CO2 caused peripheral vasodilatation, decreased arterial pressure, and increased cardiac output. Observations were made in a third group of g dogs treated with hexamethonium after having administered
propranolol (Inderal), a beta-adrenergic blocking agent. The dose of propranolol employed was sufficient to block the vascular and cardiac effects of large intravenous infusions of isoproterenol and the cardiac effects of electrical stimulation of the stellate ganglion. This dose of propranolol did not block the vasodilatation and increased cardiac output which occurred in response to carbon dioxide suggesting that these
responses are not mediated through stimulation of beta adrenergic receptors.
Details
- Title: Subtitle
- Cardiovascular responses to carbon dioxide before and after beta-adrenergic blockade
- Creators
- Michael G WendlingJohn W EcksteinFrancois M Abboud
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.22(2), pp.223-226
- DOI
- 10.1152/jappl.1967.22.2.223
- PMID
- 6017887
- NLM abbreviation
- J Appl Physiol (1985)
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Language
- English
- Date published
- 02/1967
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984025371102771
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