Journal article
Cardiovascular responses to exercise in the rat: role of corticotropin-releasing factor
Journal of applied physiology (1985), Vol.68(2), pp.561-567
02/01/1990
DOI: 10.1152/jappl.1990.68.2.561
PMID: 2318769
Abstract
The effects of intracerebroventricular (icv) administration of a corticotropin-releasing factor (CRF) receptor antagonist, alpha-helical CRF, on systemic and regional hemodynamic adjustments to exercise were studied in conscious rats. On consecutive days, rats received saline icv, alpha-helical CRF icv, and no treatment 30 min before treadmill exercise (TMX). Increases in heart rate (HR) and mean arterial pressure (MAP) in response to TMX (16.1-28.6 m/min) were similar after icv administration of saline or no treatment. In rats receiving saline icv or no treatment, estimated vascular resistance increased in the mesenteric and renal regions and declined in the iliac (hindlimb) region. After icv administration of alpha-helical CRF9-41, HR and MAP responses during TMX were significantly attenuated. In addition, TMX-induced elevations of estimated mesenteric vascular resistance and iliac blood flow velocity were blunted after CRF receptor blockade. These altered cardiovascular and hemodynamic responses were ultimately reflected in the animals' compromised ability to run. The results suggest that the central nervous system actions of endogenous CRF are necessary for the full expression of the cardiovascular adjustments to TMX in the conscious rat.
Details
- Title: Subtitle
- Cardiovascular responses to exercise in the rat: role of corticotropin-releasing factor
- Creators
- Kevin C Kregel - Department of Exercise and Sport Sciences, University of Arizona, Tucson 85721J Michael Overton - Department of Exercise and Sport Sciences, University of Arizona, Tucson 85721Douglas R Seals - Department of Exercise and Sport Sciences, University of Arizona, Tucson 85721Charles M Tipton - Department of Exercise and Sport Sciences, University of Arizona, Tucson 85721Laurel A Fisher - Department of Exercise and Sport Sciences, University of Arizona, Tucson 85721
- Resource Type
- Journal article
- Publication Details
- Journal of applied physiology (1985), Vol.68(2), pp.561-567
- DOI
- 10.1152/jappl.1990.68.2.561
- PMID
- 2318769
- ISSN
- 8750-7587
- eISSN
- 1522-1601
- Language
- English
- Date published
- 02/01/1990
- Academic Unit
- Radiation Oncology; Provost Office Administration; Health and Human Physiology
- Record Identifier
- 9984213308502771
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