Journal article
Cardiovascular risk factors and cognitive performance in aging
Dementia & neuropsychologia, Vol.11(4), pp.442-448
12/01/2017
DOI: 10.1590/1980-57642016dn11-040015
PMCID: PMC5770004
PMID: 29354226
Abstract
Background. Atherosclerosis in cerebral blood vessels, especially those which compose the Circle of Willis, can lead to reduced supply of oxygen and nutrients to different cortical structures, affecting cognitive function. Objective: To analyze whether cardiovascular risk factors negatively influence cognitive performance in adults and elderly. Methods: One hundred twenty-nine participants of both sexes, aged over 50 years, without cognitive or functional impairment were included. Body mass index (BMI), hypertension (HTN), diabetes mellitus (DM), smoking history, plasma levels of total cholesterol, low density lipoproteins (LDL), high density lipoproteins (HDL) and very low density lipoproteins (VLDL) cholesterol, triglycerides, and glucose were the cardiovascular risk factors analyzed. Cognitive assessment was performed using tests of attention, working memory, category fluency and declarative memory. Results: Controlling for age and education, multivariate linear regression models revealed that higher concentrations of triglycerides, as well as total, LDL and VLDL cholesterol, were associated with poorer performance on the digit span and category fluency tests. Higher HDL concentrations were associated with higher scores on category fluency tasks. Furthermore, higher BMI was associated with poorer delayed recall performance. Conclusion: The findings revealed that cardiovascular risk factors may negatively impact cognitive performance in aging.
Details
- Title: Subtitle
- Cardiovascular risk factors and cognitive performance in aging
- Creators
- Juliana Rumy Tsuchihashi Takeda - Universidade de São PauloTatiane Martins Matos - Universidade de São PauloJuliana Nery de Souza-Talarico - Universidade de São Paulo
- Resource Type
- Journal article
- Publication Details
- Dementia & neuropsychologia, Vol.11(4), pp.442-448
- DOI
- 10.1590/1980-57642016dn11-040015
- PMID
- 29354226
- PMCID
- PMC5770004
- NLM abbreviation
- Dement Neuropsychol
- ISSN
- 1980-5764
- eISSN
- 1980-5764
- Publisher
- Associação de Neurologia Cognitiva e do Comportamento
- Alternative title
- FATORES DE RISCO CARDIOVASCULAR E DESEMPENHO COGNITIVO NO ENVELHECIMENTO
- Language
- Portuguese
- Date published
- 12/01/2017
- Academic Unit
- Iowa Neuroscience Institute; Nursing
- Record Identifier
- 9984065472902771
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