Journal article
Cardiovascular risk factors before and during pregnancy: Does pregnancy unmask or initiate risk?
The journal of obstetrics and gynaecology research, Vol.47(11), pp.3849-3856
11/01/2021
DOI: 10.1111/jog.14971
PMCID: PMC8924930
PMID: 34482586
Abstract
Objectives To understand if pregnancy unmasks previously silent cardiovascular (CV) adverse factors, or initiates lasting injury. Methods Pre-pregnancy and during pregnancy CV risk factors (blood pressure, fasting lipids, and glucose) from 296 women belonging to studies in the International Childhood Cardiovascular Cohort (i3C) Consortium, a group of studies assessing the relationship between child and adolescent CV risk factors and adult outcomes, were used. Correlation coefficients between the pre- and during pregnancy measures were calculated, and the mean difference between the measures was modeled with adjustment for age, body mass index, race, smoking, and study. Results Measures were strongly correlated at pre- and during-pregnancy visits (p < 0.01), with r of between 0.30 and 0.55. In most cases, the difference between pre-pregnancy and during-pregnancy did not differ significantly from 0 after adjustment for confounders. Stratification by gestational age indicated stronger correlations with measurements obtained during the first and second trimesters than the third. The correlation did not differ by the time elapsed between the pre-pregnancy and pregnancy visits. Conclusions Pre- and during-pregnancy CV risk factors are moderately well correlated. This may indicate that susceptible women enter pregnancy with higher risk rather than pregnancy inducing new vascular or metabolic effects.
Details
- Title: Subtitle
- Cardiovascular risk factors before and during pregnancy: Does pregnancy unmask or initiate risk?
- Creators
- Emily W. Harville - Tulane UniversityCarrie E. Crook - Tulane UniversityLydia A. Bazzano - Tulane UniversityJessica G. Woo - Cincinnati Children's Hospital Medical CenterTrudy L. Burns - University of IowaOlli Raitakari - University of TurkuElaine M. Urbina - Cincinnati Children's Hospital Medical CenterAlison Venn - University of TasmaniaDavid R. Jacobs - University of MinnesotaJulia Steinberger - University of MinnesotaAlan Sinaiko - University of MinnesotaTerence Dwyer - The George Institute for Global HealthMarkus Juonala - Turku University Hospitali3C Consortium
- Resource Type
- Journal article
- Publication Details
- The journal of obstetrics and gynaecology research, Vol.47(11), pp.3849-3856
- DOI
- 10.1111/jog.14971
- PMID
- 34482586
- PMCID
- PMC8924930
- NLM abbreviation
- J Obstet Gynaecol Res
- ISSN
- 1341-8076
- eISSN
- 1447-0756
- Publisher
- Wiley
- Number of pages
- 8
- Grant note
- NIH - Academy of Finland R01HL121230 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01HD069587 / Eunice Kennedy Shriver National Institute of Child Health and Human Development; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD) U54 GM104940 / National Institute of General Medical Sciences of the National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS)
- Language
- English
- Date published
- 11/01/2021
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984363626502771
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