Journal article
Cardiovascular, thermoregulatory, and autonomic effects of pretreatment with clonidine (C) or lisinopril (L) on recovery from exertional heat stress (ExHs) in rats
The FASEB journal, Vol.25(S1), pp.1052.4-1052.4
04/2011
DOI: 10.1096/fasebj.25.1_supplement.1052.4
Abstract
During recovery from ExHs, high frequency (HF) heart rate (HR) variability is reduced and low frequency (LF) blood pressure (BP) variability is elevated. Thus, altered autonomic function may contribute to ExHs‐induced morbidity and mortality. We studied recovery from ExHs following pretreatment with C (30mg/kg/day, n=11), L (3mg/kg/day, n=8), or placebo (P, n=8) in rats. Drugs were given 24 h and immediately before ExHs (running wheel, 6–9 m/min, 39°C). BP, HR, and core temperature (Tc) were recorded telemetrically. During recovery from ExHs, BP was lower in L (109±3 mmHg) compared to C (117±3 mmHg) or P (118±3 mmHg). HR and Tc were lower in C (330±8 bpm; 37.8±0.1 oC) compared to L (373±10 bpm; 38.2±0.2 oC) and P (360±7 bpm; 38.1±0.1). LF HR variability (sympathetic cardiac modulation) was reduced in L (9.3±0.9 %) compared to C (16.0±2.3 %) and P (15.1±2.0 %), while LF BP variability (sympathetic vascular modulation) was reduced in L (3.4±0.6 mmHg2) and C (3.9±0.5 mmHg2) compared to P (5.5±0.9 mmHg2). In conclusion, C improves thermoregulation following ExHs as indicated by a lower Tc. Because of the linear relationship between HR and metabolic rate, the lower HR in C suggests that this effect may be mediated by a lower metabolic rate. Both drugs reduce sympathetic modulation of cardiovascular end‐organ function, which may contribute to improved recovery following ExHs. Support: USAMRMC; not official US Army or DoD policy.
Details
- Title: Subtitle
- Cardiovascular, thermoregulatory, and autonomic effects of pretreatment with clonidine (C) or lisinopril (L) on recovery from exertional heat stress (ExHs) in rats
- Creators
- Harald Martin Stauss - The University of IowaFrederick O Liaboe - The University of IowaRobert Ingram - The University of IowaLisa R Leon - US Army Research Institute of Environmental MedicineKevin C Kregel - The University of Iowa
- Resource Type
- Journal article
- Publication Details
- The FASEB journal, Vol.25(S1), pp.1052.4-1052.4
- Publisher
- Federation of American Societies for Experimental Biology
- DOI
- 10.1096/fasebj.25.1_supplement.1052.4
- ISSN
- 0892-6638
- eISSN
- 1530-6860
- Number of pages
- 1
- Grant note
- US Army DoD USAMRMC
- Language
- English
- Date published
- 04/2011
- Academic Unit
- Radiation Oncology; Provost Office Administration; Health and Human Physiology
- Record Identifier
- 9984213457602771
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