Journal article
Carotid Artery Stiffness is Associated With Cognitive Performance in Former Smokers With and Without Chronic Obstructive Pulmonary Disease
Journal of the American Heart Association, Vol.9(9), pp.e014862-e014862
05/05/2020
DOI: 10.1161/JAHA.119.014862
PMCID: PMC7428572
PMID: 32338117
Abstract
Background Heavy smokers perform worse on neuropsychological assessment than age-matched peers. However, traditional pulmonary measures of airflow limitation and hypoxemia explain only a modest amount of variance in cognition. The current objective was to determine whether carotid artery stiffness is associated with cognition in former smokers beyond the effects of amount of smoking and pulmonary function. Methods and Results Eighty-four former smokers including individuals across a spectrum of airflow limitation severity were included: 30 without chronic obstructive pulmonary disease (Global Initiative for Chronic Obstructive Lung Disease [GOLD] 0 with normal spirometry and lung computed tomography), 31 with mild-moderate chronic obstructive pulmonary disease (GOLD 1-2), and 23 with severe-very severe chronic obstructive pulmonary disease (GOLD 3-4). Participants completed questionnaires, spirometry, carotid ultrasonography, and neuropsychological testing. Multiple linear regression was used to determine whether carotid artery stiffness is associated with neuropsychological performance in 4 cognitive domains after adjusting for age, sex, pack-years of smoking, estimated premorbid intellectual functioning, and airflow limitation. Higher carotid artery β-stiffness index was associated with reduced executive functioning-processing speed in the fully adjusted model (β=-0.49, SE=0.14;
=0.001). Lower premorbid intellectual function, male sex, and presence of airflow limitation (GOLD 1 or 2 and GOLD 3 or 4) were also associated with worse executive functioning-processing speed. β-Stiffness index was not significantly associated with performance in other cognitive domains. Conclusions Carotid artery stiffness is associated with worse performance on executive functioning-processing speed in former smokers beyond the effects of aging, amount of past smoking, severity of airflow limitation, and hypoxemia. Future research should examine whether carotid stiffness can be used to identify former smokers at risk for subsequent cognitive impairment.
Details
- Title: Subtitle
- Carotid Artery Stiffness is Associated With Cognitive Performance in Former Smokers With and Without Chronic Obstructive Pulmonary Disease
- Creators
- Karin F Hoth - Medicine National Jewish Health Denver COKerrie L Moreau - Medicine University of Colorado Anschutz Medical Campus Aurora COHoward D Weinberger - Medicine University of Colorado Anschutz Medical Campus Aurora COKristen E Holm - Community and Behavioral Health University of Colorado School of Public Health Aurora COKimberly Meschede - Medicine National Jewish Health Denver COJames D Crapo - Medicine University of Colorado Anschutz Medical Campus Aurora COBarry J Make - Medicine University of Colorado Anschutz Medical Campus Aurora CODavid J Moser - Psychiatry University of Iowa Iowa City IAElizabeth Kozora - Psychiatry University of Colorado Anschutz Medical Campus Aurora CORussell P Bowler - Medicine University of Colorado Anschutz Medical Campus Aurora COGary L Pierce - Environmental Health Sciences Research Center University of Iowa Iowa City IAPatrick Ten Eyck - Institute for Clinical and Translational Science University of Iowa Iowa City IAFrederick S Wamboldt - Psychiatry University of Colorado Anschutz Medical Campus Aurora CO
- Resource Type
- Journal article
- Publication Details
- Journal of the American Heart Association, Vol.9(9), pp.e014862-e014862
- Publisher
- England
- DOI
- 10.1161/JAHA.119.014862
- PMID
- 32338117
- PMCID
- PMC7428572
- ISSN
- 2047-9980
- eISSN
- 2047-9980
- Grant note
- P30 ES005605 / NIEHS NIH HHS U01 HL089856 / NHLBI NIH HHS UL1 TR002537 / NCATS NIH HHS U54 TR001356 / NCATS NIH HHS UL1 TR001082 / NCATS NIH HHS K23 HL095658 / NHLBI NIH HHS U01 HL089897 / NHLBI NIH HHS UL1 TR002535 / NCATS NIH HHS R01 HL089897 / NHLBI NIH HHS
- Language
- English
- Date published
- 05/05/2020
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute; Biostatistics; Medicine Administration; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984066145902771
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