Journal article
Carotid and cardiopulmonary baroreceptor control of splanchnic and forearm vascular resistance during venous pooling in man
The Journal of physiology, Vol.286(1), pp.173-184
01/01/1979
DOI: 10.1113/jphysiol.1979.sp012612
PMCID: PMC1281564
PMID: 439023
Abstract
1. This study evaluated the contribution of carotid and cardiopulmonary baroreceptors to reflex splanchnic and forearm vascular adjustments during venous pooling in man. We compared (a) responses to lower body suction which produces venous pooling with (b) responses to lower body suction plus simultaneous application of neck suction. The rationale was that simultaneous application of neck suction, which stretches carotid baroreceptors, would minimize the contribution of carotid baroreceptors to circulatory adjustments produced by lower body suction.
2. Lower body suction at 40 mmHg decreased central venous pressure and arterial pulse pressure and increased forearm vascular resistance (plethysmography), splanchnic vascular resistance (indocyanine green dye clearance), and heart rate. Simultaneous application of neck suction prevented the tachycardia and most of the splanchnic vasoconstriction during lower body suction, but did not significantly attenuate the forearm vasoconstriction.
3. The major findings in this study are first, that the splanchnic vasoconstrictor response during venous pooling is mediated primarily through carotid baroreceptors, and secondly, that carotid and cardiopulmonary baroreceptors produce strikingly contrasting and non‐uniform regional vascular responses during venous pooling. Cardiopulmonary baroreceptors exert the predominant influence on forearm vascular resistance, but appear to have only a minor influence on splanchnic vascular resistance. Carotid baroreceptors produce most of the splanchnic vasoconstriction during venous pooling. but have a minor role in the forearm vasoconstriction.
Details
- Title: Subtitle
- Carotid and cardiopulmonary baroreceptor control of splanchnic and forearm vascular resistance during venous pooling in man
- Creators
- Francois M AbboudDwain L EckbergU. James JohannsenAllyn L Mark
- Resource Type
- Journal article
- Publication Details
- The Journal of physiology, Vol.286(1), pp.173-184
- DOI
- 10.1113/jphysiol.1979.sp012612
- PMID
- 439023
- PMCID
- PMC1281564
- NLM abbreviation
- J Physiol
- ISSN
- 0022-3751
- eISSN
- 1469-7793
- Number of pages
- 12
- Language
- English
- Date published
- 01/01/1979
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984025680902771
Metrics
28 Record Views