Cartilage-on-cartilage versus metal-on-cartilage impact characteristics and responses

Anneliese D Heiner; Abigail D Smith; Jessica E Goetz; Curtis M Goreham-Voss; Kyle T Judd; Todd O McKinley; James A Martin

doi:10.1002/jor.22311

Back

Cartilage-on-cartilage versus metal-on-cartilage impact characteristics and responses

Journal article

Open access

Peer reviewed

Cartilage-on-cartilage versus metal-on-cartilage impact characteristics and responses

Anneliese D Heiner, Abigail D Smith, Jessica E Goetz, Curtis M Goreham-Voss, Kyle T Judd, Todd O McKinley and James A Martin

Journal of orthopaedic research, Vol.31(6), pp.887-893

06/2013

DOI: 10.1002/jor.22311

PMCID: PMC3740544

PMID: 23335281

Files and links (1)

url

https://doi.org/10.1002/jor.22311View

Published (Version of record) Open Access

Abstract

A common in vitro model for studying acute mechanical damage in cartilage is to impact an isolated osteochondral or cartilage specimen with a metallic impactor. The mechanics of a cartilage-on-cartilage (COC) impact, as encountered in vivo, are likely different than those of a metal-on-cartilage (MOC) impact. The hypothesis of this study was that impacted in vitro COC and MOC specimens would differ in their impact behavior, mechanical properties, chondrocyte viability, cell metabolism, and histologic structural damage. Osteochondral specimens were impacted with either an osteochondral plug or a metallic cylinder at the same delivered impact energy per unit area, and processed after 14 days in culture. The COC impacts resulted in about half of the impact maximum stress and a quarter of the impact maximum stress rate of change, as compared to the MOC impacts. The impacted COC specimens had smaller changes in mechanical properties, smaller decreases in chondrocyte viability, higher total proteoglycan content, and less histologic structural damage, as compared to the impacted MOC specimens. If MOC impact conditions are to be used for modeling of articular injuries and post-traumatic osteoarthritis, the differences between COC and MOC impacts must be kept in mind.

Animals

Chondrocytes - physiology

Cattle

Cartilage, Articular - injuries

Stress, Mechanical

Copper

Osteoarthritis - etiology

Zinc

Details

Title: Subtitle: Cartilage-on-cartilage versus metal-on-cartilage impact characteristics and responses
Creators: Anneliese D Heiner - Department of Orthopaedics and Rehabilitation, University of Iowa, Iowa City, Iowa, USA. anneliese-heiner@uiowa.edu
Abigail D Smith
Jessica E Goetz
Curtis M Goreham-Voss
Kyle T Judd
Todd O McKinley
James A Martin
Resource Type: Journal article
Publication Details: Journal of orthopaedic research, Vol.31(6), pp.887-893
Publisher: United States
DOI: 10.1002/jor.22311
PMID: 23335281
PMCID: PMC3740544
ISSN: 0736-0266
eISSN: 1554-527X
Grant note: P50 AR055533 / NIAMS NIH HHS
Language: English
Date published: 06/2013
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics; Orthopedics and Rehabilitation
Record Identifier: 9984040391302771

Metrics

20 Record Views

12 Times Cited - Web of Science

See more details