Case-Control Pilot Study on Acute Diarrheal Disease in a Geographically Defined Pediatric Population in a Middle Income Country

Ana E. Farfan-Garica; Chengxian Zhang; Aamer Imdad; Monica Y. Arias-Guerrero; Nayibe T. Sanchez-Alvarez; Rikhil Shah; Junaid Iqbal; Maria E. Tamborski; Oscar G. Gomez-Duarte

doi:10.1155/2017/6357597

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Case-Control Pilot Study on Acute Diarrheal Disease in a Geographically Defined Pediatric Population in a Middle Income Country

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Case-Control Pilot Study on Acute Diarrheal Disease in a Geographically Defined Pediatric Population in a Middle Income Country

Ana E. Farfan-Garica, Chengxian Zhang, Aamer Imdad, Monica Y. Arias-Guerrero, Nayibe T. Sanchez-Alvarez, Rikhil Shah, Junaid Iqbal, Maria E. Tamborski and Oscar G. Gomez-Duarte

International journal of pediatrics, Vol.2017, pp.6357597-10

01/01/2017

DOI: 10.1155/2017/6357597

PMCID: PMC5569627

PMID: 28855919

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Abstract

Introduction. Acute diarrheal disease (ADD) is a common cause of morbidity and mortality in children under 5 years of age. Understanding of the etiology of ADD is lacking in most low and middle income countries because reference laboratories detect limited number of pathogens. The objective of this study was to determine the feasibility to conduct a comprehensive case-control study to survey diarrheal pathogens among children with and without moderate-to-severe ADD. Materials and Methods. Microbiology and molecular-based techniques were used to detect viral, bacterial, and parasitic enteropathogens. The study was conducted in Bucaramanga, Colombia, after Institutional Review Board approval was obtained. Results. Ninety children less than 5 years of age were recruited after a written informed consent was obtained from parents or guardians. Forty-five subjects served as cases with ADD and 45 as controls. Thirty-six subjects out of 90 (40.0%) were positive for at least one enteropathogen, that is, 20 (44.4%) cases and 16 (35.5%) controls. Conclusions. The three most common enteric pathogens were enteroaggregative E. coli (10.0%), Norovirus (6.7%), and Salmonella spp. (5.6%). The E. coli pathogens were 18.8% of all infections making them the most frequent pathogens. Half of ADD cases were negative for any pathogens.

Life Sciences & Biomedicine

Pediatrics

Science & Technology

Details

Title: Subtitle: Case-Control Pilot Study on Acute Diarrheal Disease in a Geographically Defined Pediatric Population in a Middle Income Country
Creators: Ana E. Farfan-Garica - Universidad De Santander
Chengxian Zhang - Vanderbilt University
Aamer Imdad - Vanderbilt University
Monica Y. Arias-Guerrero - Universidad De Santander
Nayibe T. Sanchez-Alvarez - Universidad De Santander
Rikhil Shah - Vanderbilt University
Junaid Iqbal - Vanderbilt University
Maria E. Tamborski - Vanderbilt University
Oscar G. Gomez-Duarte - Vanderbilt University
Resource Type: Journal article
Publication Details: International journal of pediatrics, Vol.2017, pp.6357597-10
DOI: 10.1155/2017/6357597
PMID: 28855919
PMCID: PMC5569627
NLM abbreviation: Int J Pediatr
ISSN: 1687-9740
eISSN: 1687-9759
Publisher: Hindawi Publishing Group
Number of pages: 10
Grant note: R01-AI095346 / NIH-NIAID; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID) R01AI095346 / NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Allergy & Infectious Diseases (NIAID)
Language: English
Date published: 01/01/2017
Academic Unit: Stead Family Department of Pediatrics; Gastroenterology, Hepatology, Pancreatology, and Nutrition
Record Identifier: 9984446731802771

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