Journal article
Case Report: Stimulation of the Right Amygdala Induces Transient Changes in Affective Bias
Brain stimulation, Vol.7(5), pp.690-693
09/2014
DOI: 10.1016/j.brs.2014.05.005
PMCID: PMC4167906
PMID: 24972588
Abstract
Sensitive outcome measures are needed to quantify the effects of neuromodulation in mood disorders.
This study examined the utility of a novel affective bias (AB) task in identifying transient mood changes induced by amygdala stimulation in a single rare participant.
Localized, pulsed electrical stimulation was delivered for 8 min during measures of AB and self-reported mood. Responses were compared with those gathered without stimulation on the same day in the same setting, using paired t-tests.
Stimulation of the basolateral nucleus of the right amygdala at 50 Hz, 15 V, and 200 μs pulse-width produced a significant positive shift in AB (t = −2.864, df = 53, P = .006), despite equivocal findings on self-reported mood (t = −.184, df = 12, P = .857).
Affective bias may be more sensitive to stimulation-induced fluctuations in mood than subjective report, suggesting utility as an outcome measure in neuromodulation studies.
Details
- Title: Subtitle
- Case Report: Stimulation of the Right Amygdala Induces Transient Changes in Affective Bias
- Creators
- Kelly R Bijanki - Department of Psychiatry, University of Iowa Carver College of Medicine, USAChristopher K Kovach - Department of Neurosurgery, University of Iowa Carver College of Medicine, USALaurie M McCormick - Department of Psychiatry, University of Iowa Carver College of Medicine, USAHiroto Kawasaki - Department of Neurosurgery, University of Iowa Carver College of Medicine, USABrian J Dlouhy - Department of Neurosurgery, University of Iowa Carver College of Medicine, USAJustin Feinstein - Department of Neurology, University of Iowa Carver College of Medicine, USARobert D Jones - Department of Neurology, University of Iowa Carver College of Medicine, USAMatthew A Howard - Department of Neurosurgery, University of Iowa Carver College of Medicine, USA
- Resource Type
- Journal article
- Publication Details
- Brain stimulation, Vol.7(5), pp.690-693
- DOI
- 10.1016/j.brs.2014.05.005
- PMID
- 24972588
- PMCID
- PMC4167906
- NLM abbreviation
- Brain Stimul
- ISSN
- 1935-861X
- eISSN
- 1876-4754
- Publisher
- Elsevier Inc
- Grant note
- 5R01DC004290-14 / National Institute on Deafness and Other Communication Disorders (http://dx.doi.org/10.13039/100000055)
- Language
- English
- Date published
- 09/2014
- Academic Unit
- Neurology; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
- Record Identifier
- 9984020616802771
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