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Case-control association study of TGOLN2 in attempted suicide
Journal article   Open access   Peer reviewed

Case-control association study of TGOLN2 in attempted suicide

Pamela B Mahon, Adrian M Stütz, Fayaz Seifuddin, Yuqing Huo, Fernando S Goes, Dubravka Jancic, Jennifer T Judy, J Raymond Depaulo Jr, Elliot S Gershon, Francis J McMahon, …
American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.153B(5), pp.1016-1023
07/2010
DOI: 10.1002/ajmg.b.31068
PMCID: PMC3645851
PMID: 20468057
url
https://www.ncbi.nlm.nih.gov/pmc/articles/3645851View
Open Access

Abstract

Family, twin, and adoption studies provide convincing evidence for a genetic contribution to suicidal behavior. The heritability for suicidal behavior depends in part on the transmission of psychiatric disorders, such as mood disorders and substance use disorders, but is also partly independent of them. Three linkage studies using the attempted suicide phenotype in pedigrees with bipolar disorder, major depression, or alcoholism have provided consistent evidence that 2p11-12 harbors a susceptibility gene for attempted suicide. A microarray expression study using postmortem brain samples has implicated a gene from the 2p11-12 candidate region, the trans-Golgi network protein 2 (TGOLN2) gene, as being consistently up-regulated in suicide cases as compared to controls. Here, we present a TGOLN2 case-control association study using nine single nucleotide polymorphisms (SNPs). These nine SNPs, which include seven tag SNPs and two coding SNPs, have been genotyped in 517 mood disorder subjects with a history of attempted suicide and 515 normal controls. Allelic and genotypic analyses of the case-control sample did not provide evidence for association with the attempted suicide phenotype. Eight of the nine SNPs provided supportive evidence for association (P-values ranging from 0.008 to 0.03) when we compared the attempted suicide cases with a history of alcoholism to the attempted suicide cases without a history of alcoholism. However, this association finding was not replicated in an independent sample. Taken together, these analyses do not provide support for the hypothesis that common genetic variation in TGOLN2 contributes significantly to the risk for attempted suicide in subjects with major mood disorders.
 Genetic Predisposition to Disease Reproducibility of Results Genetic Association Studies Humans Middle Aged Male Case-Control Studies Membrane Glycoproteins - genetics Haplotypes - genetics Suicide, Attempted Alleles Polymorphism, Single Nucleotide - genetics Adult Alcoholism - genetics Female Alcoholism - complications Odds Ratio

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