Case of progressive dysplasia concomitant with intralesional cidofovir administration for recurrent respiratory papillomatosis

Richard D Wemer; John H Lee; Henry T Hoffman; Robert A Robinson; Richard J H Smith

doi:10.1177/000348940511401105

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Case of progressive dysplasia concomitant with intralesional cidofovir administration for recurrent respiratory papillomatosis

Journal article

Peer reviewed

Case of progressive dysplasia concomitant with intralesional cidofovir administration for recurrent respiratory papillomatosis

Richard D Wemer, John H Lee, Henry T Hoffman, Robert A Robinson and Richard J H Smith

Annals of otology, rhinology & laryngology, Vol.114(11), pp.836-839

11/2005

DOI: 10.1177/000348940511401105

PMID: 16358603

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Abstract

Recurrent respiratory papillomatosis (RRP) is characterized by benign wartlike growths in the larynx with occasional spread to the lungs. A broad range of therapeutic measures have been used to treat RRP; the primary treatment is laser vaporization of the lesions. Recurrences of the disease are common, and alternate methods of treatment are being used to prevent recurrence, including cidofovir. Cidofovir is a cytosine nucleotide analog with antiviral properties that is approved by the US Food and Drug Administration for treatment of cytomegalovirus retinitis and is currently being used off-label for RRP. Cidofovir has gained initial success in slowing the rate of disease recurrence when used at the time of surgery. However, the use of cidofovir lends concern to several adverse side effects, including the potential for carcinogenesis. We report here a 28-year-old woman who was treated with intralesional cidofovir at the time of surgery over the span of 27 months. The initial pathology results demonstrated benign disease with progression to severe dysplasia during the treatment time. Cidofovir's potential for carcinogenicity remains largely undefined, and thus, we are currently undertaking a project involving the evaluation of sequential paraffin-embedded samples of resections from a large cohort of patients with RRP treated at the University of Iowa Hospitals and Clinics.

Cytosine - analogs & derivatives

Humans

Neoplasm Recurrence, Local

Cytosine - administration & dosage

Antineoplastic Agents - administration & dosage

Disease Progression

Laryngeal Neoplasms - pathology

Organophosphonates - administration & dosage

Injections, Intralesional

Laryngeal Neoplasms - drug therapy

Adult

Female

Papilloma - pathology

Papilloma - drug therapy

Details

Title: Subtitle: Case of progressive dysplasia concomitant with intralesional cidofovir administration for recurrent respiratory papillomatosis
Creators: Richard D Wemer - Department of Otolaryngology-Head and Neck Surgery, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
John H Lee
Henry T Hoffman
Robert A Robinson
Richard J H Smith
Resource Type: Journal article
Publication Details: Annals of otology, rhinology & laryngology, Vol.114(11), pp.836-839
DOI: 10.1177/000348940511401105
PMID: 16358603
NLM abbreviation: Ann Otol Rhinol Laryngol
ISSN: 0003-4894
eISSN: 1943-572X
Publisher: United States
Language: English
Date published: 11/2005
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Oral Pathology, Radiology and Medicine; Anatomy and Cell Biology; Stead Family Department of Pediatrics; Pathology; Iowa Neuroscience Institute; Radiation Oncology; Otolaryngology; Internal Medicine
Record Identifier: 9984006336502771

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