Journal article
Case report: Disseminated herpes simplex virus 1 infection and hemophagocytic lymphohistiocytosis after immunomodulatory therapy in a patient with coronavirus disease 2019
Frontiers in medicine, Vol.9, p.1053012
11/21/2022
DOI: 10.3389/fmed.2022.1053012
PMCID: PMC9720054
PMID: 36479095
Abstract
Corticosteroids and immunomodulatory therapies are widely used to treat patients with severe coronavirus disease 2019 (COVID-19). Janus kinase (JAK) inhibitors such as tofacitinib have been recently studied as adjuvants in the treatment of COVID-19. Although immunomodulatory therapies may be linked to decreased mortality rates in the acute phase, subsequent severe infectious complications may result from them. We describe a case of a multiorgan system failure secondary to disseminated primary herpes simplex virus 1 (HSV-1) infection and hemophagocytic lymphohistiocytosis (HLH) following treatment with tofacitinib and high-dose dexamethasone therapy for severe COVID-19. Early diagnosis and treatment of these life-threatening conditions may have a significant impact on COVID-19 patients' outcomes.
Details
- Title: Subtitle
- Case report: Disseminated herpes simplex virus 1 infection and hemophagocytic lymphohistiocytosis after immunomodulatory therapy in a patient with coronavirus disease 2019
- Creators
- Elvio Mazzotta - The Ohio State University Wexner Medical CenterJuan Fiorda Diaz - The Ohio State University Wexner Medical CenterMarco Echeverria-Villalobos - The Ohio State UniversityGregory Eisinger - The Ohio State University Wexner Medical CenterSarah Sprauer - The Ohio State University Wexner Medical CenterArindam Singha - The Ohio State University Wexner Medical CenterMichael R. R. Lyaker - The Ohio State University Wexner Medical Center
- Resource Type
- Journal article
- Publication Details
- Frontiers in medicine, Vol.9, p.1053012
- Publisher
- Frontiers Media Sa
- DOI
- 10.3389/fmed.2022.1053012
- PMID
- 36479095
- PMCID
- PMC9720054
- ISSN
- 2296-858X
- eISSN
- 2296-858X
- Number of pages
- 5
- Language
- English
- Date published
- 11/21/2022
- Academic Unit
- Anesthesia
- Record Identifier
- 9984656539802771
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