Case report: paroxysmal cold hemoglobinuria presenting during pregnancy

Andrea O Akpoguma; Thomas L Carlisle; Steven R Lentz

doi:10.1186/s12878-015-0023-7

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Case report: paroxysmal cold hemoglobinuria presenting during pregnancy

Journal article

Open access

Peer reviewed

Case report: paroxysmal cold hemoglobinuria presenting during pregnancy

Andrea O Akpoguma, Thomas L Carlisle and Steven R Lentz

BMC hematology, Vol.15(1), pp.3-3

2015

DOI: 10.1186/s12878-015-0023-7

PMCID: PMC4334594

PMID: 25699184

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https://doi.org/10.1186/s12878-015-0023-7View

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Abstract

Background: Paroxysmal cold hemoglobinuria is caused by a biphasic IgG autoantibody that triggers complement-mediated intravascular hemolysis. Paroxysmal cold hemoglobinuria has not previously been reported to occur in association with pregnancy. Case presentation: We report a case of an 18 year old female who presented in early pregnancy with acute hemolytic anemia and a positive Donath-Landsteiner antibody test. She was diagnosed with paroxysmal cold hemoglobinuria and treated supportively. Her hemolysis resolved within 6 weeks. Because maternal IgG autoantibodies can cross the placenta, the patient was monitored closely throughout her pregnancy for recurrence. The outcome of the pregnancy was successful, with no evidence of neonatal anemia or hemolysis. Conclusion: This patient had a classic presentation of paroxysmal cold hemoglobinuria with rapid onset of hemolytic anemia that resolved spontaneously. To our knowledge, this is the first report of paroxysmal cold hemoglobinuria presenting during pregnancy.

Pregnancy

Hemolytic anemia

Paroxysmal cold hemoglobinuria

Case Report

Donath-Landsteiner antibody

Details

Title: Subtitle: Case report: paroxysmal cold hemoglobinuria presenting during pregnancy
Creators: Andrea O Akpoguma - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA USA
Thomas L Carlisle - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA USA
Steven R Lentz - Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, IA USA
Resource Type: Journal article
Publication Details: BMC hematology, Vol.15(1), pp.3-3
DOI: 10.1186/s12878-015-0023-7
PMID: 25699184
PMCID: PMC4334594
NLM abbreviation: BMC Hematol
ISSN: 2052-1839
eISSN: 2052-1839
Publisher: BioMed Central
Language: English
Date published: 2015
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
Record Identifier: 9984094540102771

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