Journal article
Case report: successful treatment of recurrent focal segmental glomerulosclerosis with a novel rituximab regimen
Transplantation proceedings, Vol.43(10), pp.3994-3996
12/2011
DOI: 10.1016/j.transproceed.2011.10.051
PMID: 22172885
Abstract
Focal segmental glomerulosclerosis (FSGS) is the cause of renal failure in more than 10% of pediatric patients undergoing renal transplantation. Recurrent FSGS is a major cause of pediatric allograft failure, with the risk increasing for patients undergoing retransplantation. Standard therapy for recurrent posttransplantation FSGS includes the use of intensive plasmapheresis (PP) in conjunction with cyclophosphamide or high-dose cyclosporine. However, many patients exhibit refractory disease, with rapid progression to allograft loss despite these interventions. Prior studies have reported conflicting data on the efficacy of adding rituximab therapy to the standard treatment regimen for recurrent posttransplantation FSGS. Here we present a successful therapeutic protocol with rapid elimination of PP after initiation of rituximab therapy for an adolescent patient with recurrent FSGS in the immediate postoperative period. The patient has maintained excellent allograft function through 12 months posttransplantation.
Details
- Title: Subtitle
- Case report: successful treatment of recurrent focal segmental glomerulosclerosis with a novel rituximab regimen
- Creators
- Z A Stewart - University of Iowa Hospitals and ClinicsR Shetty - University of Iowa Hospitals and ClinicsR Nair - University of IowaA I Reed - University of IowaP D Brophy - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Transplantation proceedings, Vol.43(10), pp.3994-3996
- DOI
- 10.1016/j.transproceed.2011.10.051
- PMID
- 22172885
- ISSN
- 0041-1345
- eISSN
- 1873-2623
- Grant note
- K08 DK092284 / NIDDK NIH HHS K08 DK092284-02 / NIDDK NIH HHS
- Language
- English
- Date published
- 12/2011
- Academic Unit
- Accounting; Surgery
- Record Identifier
- 9984321869602771
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