Caspofungin activity against clinical isolates of fluconazole-resistant Candida

Michael A Pfaller; Shawn A Messer; Linda Boyken; Cassie Rice; Shailesh Tendolkar; Richard J Hollis; Daniel J Diekema

doi:10.1128/JCM.41.12.5729-5731.2003

Back

Caspofungin activity against clinical isolates of fluconazole-resistant Candida

Journal article

Open access

Peer reviewed

Caspofungin activity against clinical isolates of fluconazole-resistant Candida

Michael A Pfaller, Shawn A Messer, Linda Boyken, Cassie Rice, Shailesh Tendolkar, Richard J Hollis and Daniel J Diekema

Journal of clinical microbiology, Vol.41(12), pp.5729-5731

12/2003

DOI: 10.1128/JCM.41.12.5729-5731.2003

PMCID: PMC309007

PMID: 14662968

Files and links (1)

url

https://doi.org/10.1128/JCM.41.12.5729-5731.2003View

Published (Version of record) Open Access

Abstract

A total of 7,837 clinical isolates of Candida were tested against fluconazole, and 351 resistant (fluconazole MIC >/=64 micro g/ml) isolates were identified (4% of the total tested). All fluconazole-resistant isolates were inhibited by caspofungin at concentrations that can be exceeded by standard doses (MIC at which 90% of the isolates were inhibited, 1 micro g/ml; 99% of the MICs were </=2 micro g/ml).

Antifungal Agents - pharmacology

Fluconazole - pharmacology

Humans

Candida - isolation & purification

Peptides - pharmacology

Microbial Sensitivity Tests

Peptides, Cyclic

Candida albicans - drug effects

Candida albicans - isolation & purification

Candida glabrata - isolation & purification

Caspofungin

Echinocandins

Candida - drug effects

Lipopeptides

Candida glabrata - drug effects

Drug Resistance, Microbial - physiology

Details

Title: Subtitle: Caspofungin activity against clinical isolates of fluconazole-resistant Candida
Creators: Michael A Pfaller - Departments of Pathology, University of Iowa College of Medicine and College of Public Health, Iowa City, Iowa 52242, USA
Shawn A Messer
Linda Boyken
Cassie Rice
Shailesh Tendolkar
Richard J Hollis
Daniel J Diekema
Resource Type: Journal article
Publication Details: Journal of clinical microbiology, Vol.41(12), pp.5729-5731
DOI: 10.1128/JCM.41.12.5729-5731.2003
PMID: 14662968
PMCID: PMC309007
NLM abbreviation: J Clin Microbiol
ISSN: 0095-1137
eISSN: 1098-660X
Publisher: United States
Language: English
Date published: 12/2003
Academic Unit: Infectious Diseases; Epidemiology; Pathology; Internal Medicine
Record Identifier: 9983986364002771

Metrics

33 Record Views

82 Times Cited - Web of Science