Journal article
Catechol-O-methyltransferase genotype predicts pain severity in hospitalized burn patients
Journal of burn care & research, Vol.33(4), pp.518-523
07/01/2012
DOI: 10.1097/BCR.0b013e31823746ed
PMCID: PMC3319634
PMID: 22210062
Abstract
Increasing evidence suggests that stress system activation after burn injury may contribute to burn-related pain. If this is the case, then genetic variations influencing the function of important stress system components, such as the enzyme catechol-O-methyltransferase (COMT), may predict pain severity after thermal burn injury. The authors evaluated the association between COMT genotype and pain intensity in 57 individuals hospitalized after thermal burn injury. Consenting participants at four burn centers were genotyped and completed daily 0 to 10 numeric rating scale pain assessments on 2 consecutive days including evaluation of waking, least, and worst pain. The association between COMT genotype and individual pain outcomes was calculated using a linear mixed model adjusting for sociodemographic and burn injury characteristics. Overall pain (combination of least, worst, and waking pain scores) was significantly higher in patients with a COMT pain vulnerable genotype (6.3 [0.4] vs 5.4 [0.4], P = .037). Individuals with a COMT pain vulnerable genotype also had significantly higher “least pain” scores (3.8 [0.5] vs 2.6 [0.4], P = .017) and significantly higher pain on awakening (6.8 [0.5] vs 5.3 [0.4], P = .004). Differences in worst pain according to genotype group were not significant. COMT pain vulnerable genotype was a stronger predictor of overall pain severity than burn size, burn depth, or time from admission to pain interview assessment. These findings suggest that genetic factors influencing stress system function may have an important influence on pain severity after burn injury. Further studies of genetic predictors of pain after burn injury are needed.
Details
- Title: Subtitle
- Catechol-O-methyltransferase genotype predicts pain severity in hospitalized burn patients
- Creators
- Danielle C. Orrey - University of North Carolina at Chapel HillAndrey V. Bortsov - University of North Carolina at Chapel HillJanelle M. Hoskins - University of North Carolina at Chapel HillJeffrey W. Shupp - MedStar Washington Hospital CenterSamuel W. Jones - University of North Carolina at Chapel HillBryan J. Cicuto - University of North Carolina at Chapel HillJames Hwang - University of North Carolina at Chapel HillMarion H. Jordan - MedStar Washington Hospital CenterJames H. Holmes - Atrium Health Wake Forest BaptistLinwood R. Haith - Crozer-Keystone Health SystemBrandon M. Roane - University of North Carolina at Chapel HillLuda Diatchenko - University of North Carolina at Chapel HillBruce A. Cairns - University of North Carolina at Chapel HillSamuel A. McLean - University of North Carolina at Chapel Hill
- Resource Type
- Journal article
- Publication Details
- Journal of burn care & research, Vol.33(4), pp.518-523
- DOI
- 10.1097/BCR.0b013e31823746ed
- PMID
- 22210062
- PMCID
- PMC3319634
- NLM abbreviation
- J Burn Care Res
- ISSN
- 1559-047X
- eISSN
- 1559-0488
- Number of pages
- 6
- Grant note
- UL1 RR025747-04 || RR / National Center for Research Resources : NCRR
- Language
- English
- Date published
- 07/01/2012
- Academic Unit
- Surgery
- Record Identifier
- 9984756257602771
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