Catecholamine-induced myocardial fibrosis and oxidative stress is attenuated by Terminalia arjuna (Roxb.)

Santosh Kumar; Rajesh Enjamoori; Amardeep Jaiswal; Ruma Ray; Sandeep Seth; Subir Kumar Maulik

doi:10.1211/jpp/61.11.0013

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Catecholamine-induced myocardial fibrosis and oxidative stress is attenuated by Terminalia arjuna (Roxb.)

Journal article

Peer reviewed

Catecholamine-induced myocardial fibrosis and oxidative stress is attenuated by Terminalia arjuna (Roxb.)

Santosh Kumar, Rajesh Enjamoori, Amardeep Jaiswal, Ruma Ray, Sandeep Seth and Subir Kumar Maulik

Journal of pharmacy and pharmacology, Vol.61(11), pp.1529-1536

11/2009

DOI: 10.1211/jpp/61.11.0013

PMID: 19903379

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Abstract

Myocardial fibrosis and oxidative stress accompany a number of cardiac disorders such as hypertrophic cardiomyopathy, hypertensive heart disease and cardiac failure. Stem bark of Terminalia arjuna has been advocated for cardiac ailments. The present study evaluated the effects of T. arjuna bark extract on myocardial fibrosis and oxidative stress induced by chronic beta-adrenoceptor stimulation. Aqueous extract of T. arjuna bark was evaluated at 63, 125 and 250 mg/kg given orally for antifibrotic and antioxidant effects in rats given the selective beta-adrenoceptor agonist isoprenaline (5 mg/kg s.c.) for 28 days. Captopril (50 mg/kg per day, given orally), an inhibitor of angiotensin-converting enzyme used as a standard cardioprotective drug, was used as a positive control. Isoprenaline caused fibrosis, increased oxidative stress and cardiac hypertrophy (increased heart weight : body weight ratio and cardiomyocyte diameter). The T. arjuna bark extract and captopril significantly prevented the isoprenaline-induced increase in oxidative stress and decline in endogenous antioxidant level. Both also prevented fibrosis but not the increase in heart weight : body weight ratio. T. arjuna protects against myocardial changes induced by chronic beta-adrenoceptor stimulation.

Adrenergic beta-Agonists

Animals

Antioxidants - pharmacology

Captopril - pharmacology

Cardiomegaly - drug therapy

Fibrosis - chemically induced

Fibrosis - prevention & control

Heart - drug effects

Isoproterenol - pharmacology

Male

Myocardium - pathology

Organ Size

Oxidative Stress - drug effects

Peptidyl-Dipeptidase A

Phytotherapy

Plant Bark

Plant Extracts - pharmacology

Plant Stems

Rats

Rats, Wistar

Terminalia

Details

Title: Subtitle: Catecholamine-induced myocardial fibrosis and oxidative stress is attenuated by Terminalia arjuna (Roxb.)
Creators: Santosh Kumar - All India Institute of Medical Sciences
Rajesh Enjamoori - All India Institute of Medical Sciences
Amardeep Jaiswal - All India Institute of Medical Sciences
Ruma Ray - All India Institute of Medical Sciences
Sandeep Seth - All India Institute of Medical Sciences
Subir Kumar Maulik - All India Institute of Medical Sciences
Resource Type: Journal article
Publication Details: Journal of pharmacy and pharmacology, Vol.61(11), pp.1529-1536
DOI: 10.1211/jpp/61.11.0013
PMID: 19903379
ISSN: 0022-3573
eISSN: 2042-7158
Language: English
Date published: 11/2009
Academic Unit: Cardiovascular Medicine; Internal Medicine
Record Identifier: 9984359862302771

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