Journal article
Catecholamine-resistant hypotension and myocardial performance following patent ductus arteriosus ligation
Journal of perinatology, Vol.35(2), pp.123-127
08/14/2014
DOI: 10.1038/jp.2014.151
PMCID: PMC4310792
PMID: 25118721
Abstract
OBJECTIVE: We performed a multicenter study of preterm infants, who were about to undergo patent ductus arteriosus ligation, to determine whether echocardiographic indices of impaired myocardial performance were associated with subsequent development of catecholamine-resistant hypotension following ligation. STUDY DESIGN: A standardized treatment approach for hypotension was followed at each center. Infants were considered to have catecholamine-resistant hypotension if their dopamine infusion was >15 μg kg-1min-1. Echocardiograms and cortisol measurements were obtained between 6 and 14 h after the ligation (prior to the presence of catecholamine-resistant hypotension). RESULT: Forty-five infants were enrolled, 10 received catecholamines (6 were catecholamine-responsive and 4 developed catecholamine-resistant hypotension). Catecholamine-resistant hypotension was not associated with decreased preload, shortening fraction or ventricular output. Infants with catecholamine-resistant hypotension had significantly lower levels of systemic vascular resistance and postoperative cortisol concentration. CONCLUSION: We speculate that low cortisol levels and impaired vascular tone may have a more important role than impaired cardiac performance in post-ligation catecholamine-resistant hypotension.
Details
- Title: Subtitle
- Catecholamine-resistant hypotension and myocardial performance following patent ductus arteriosus ligation
- Creators
- Shahab Noori - Children's Hospital of Los AngelesPatrick McNamara - Hospital for Sick ChildrenAmish Jain - Mount Sinai HospitalPascal M. Lavoie - Children's & Women's Health Centre of British ColumbiaAndrea Wickremasinghe - University of California, San FranciscoT. Allen Merritt - Loma Linda UniversityTabitha Solomon - Loma Linda UniversityKrishnamurthy Sekar - University of OklahomaJoshua T. Attridge - University of VirginiaJonathan R. Swanson - University of VirginiaMaria Gillam-Krakauer - Vanderbilt UniversityJeff Reese - Vanderbilt UniversityBrenda B. Poindexter - Indiana University – Purdue University IndianapolisMichael Brook - University of California, San FranciscoRichard J. Auchus - University of MichiganRonald I. Clyman - University of California, San FranciscoPDA Ligation/Hypotension Trial Investigators
- Resource Type
- Journal article
- Publication Details
- Journal of perinatology, Vol.35(2), pp.123-127
- DOI
- 10.1038/jp.2014.151
- PMID
- 25118721
- PMCID
- PMC4310792
- NLM abbreviation
- J Perinatol
- ISSN
- 0743-8346
- eISSN
- 1476-5543
- Language
- English
- Date published
- 08/14/2014
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology; Internal Medicine
- Record Identifier
- 9984353880302771
Metrics
12 Record Views