Category-specific recognition and naming deficits following resection of a right anterior temporal lobe tumor in a patient with atypical language lateralization

Daniel L Drane; George A Ojemann; Jeffrey G Ojemann; Elizabeth Aylward; Daniel L Silbergeld; John W Miller; Daniel Tranel

doi:10.1016/j.cortex.2008.04.007

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Category-specific recognition and naming deficits following resection of a right anterior temporal lobe tumor in a patient with atypical language lateralization

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Category-specific recognition and naming deficits following resection of a right anterior temporal lobe tumor in a patient with atypical language lateralization

Daniel L Drane, George A Ojemann, Jeffrey G Ojemann, Elizabeth Aylward, Daniel L Silbergeld, John W Miller and Daniel Tranel

Cortex, Vol.45(5), pp.630-640

2009

DOI: 10.1016/j.cortex.2008.04.007

PMCID: PMC2727923

PMID: 18632095

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Abstract

We present a patient with right-hemispheric speech lateralization who exhibited severe recognition and naming deficits for unique objects (famous faces and landmarks) and grossly normal recognition and naming performances for nonunique objects (animals and man-made objects) following an anterior right temporal lobe (TL) resection of a ganglioglioma. While recognition deficits have been reported for famous faces following right temporal pole lesions, and for landmarks and geographic regions following right TL damage in general, this is the first reported case of both recognition and naming deficits for these objects resulting from a single lesion. These results are consistent with research suggesting that the neuroanatomic substrates for the recognition and naming of unique objects lie in the anterior TL regions. Left temporal pole lesions have been associated with naming deficits for unique objects while right temporal pole lesions have been associated with recognition deficits for unique objects. However, these findings suggest that the substrates of naming can be located in homotopic regions of the right hemisphere when language lateralization is atypical. As various object categories appear to have different neuroanatomical representations in the TLs, we discuss the possible benefits of sampling a wider array of objects during cortical stimulation mapping of language.

Tumor resection

Atypical speech lateralization

Temporal lobes

Semantic memory

Category-specific naming and recognition deficits

Details

Title: Subtitle: Category-specific recognition and naming deficits following resection of a right anterior temporal lobe tumor in a patient with atypical language lateralization
Creators: Daniel L Drane - Department of Neurology, University of Washington, Seattle, WA, USA
George A Ojemann - UW Regional Epilepsy Center, Harborview Medical Center, Seattle, WA, USA
Jeffrey G Ojemann - UW Regional Epilepsy Center, Harborview Medical Center, Seattle, WA, USA
Elizabeth Aylward - Department of Radiology, University of Washington, Seattle, WA, USA
Daniel L Silbergeld - UW Regional Epilepsy Center, Harborview Medical Center, Seattle, WA, USA
John W Miller - Department of Neurology, University of Washington, Seattle, WA, USA
Daniel Tranel - Department of Neurology, University of Iowa College of Medicine, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Cortex, Vol.45(5), pp.630-640
DOI: 10.1016/j.cortex.2008.04.007
PMID: 18632095
PMCID: PMC2727923
NLM abbreviation: Cortex
ISSN: 0010-9452
eISSN: 1973-8102
Publisher: Elsevier Srl
Language: English
Date published: 2009
Academic Unit: Neurology; Electrical and Computer Engineering; Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984002497802771

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