Journal article
Cationic CaMKII Inhibiting Nanoparticles Prevent Allergic Asthma
Molecular pharmaceutics, Vol.14(6), pp.2166-2175
06/05/2017
DOI: 10.1021/acs.molpharmaceut.7b00114
PMCID: PMC5800301
PMID: 28460526
Abstract
Asthma is a common lung disease affecting over 300 million people worldwide and is associated with increased reactive oxygen species, eosinophilic airway inflammation, bronchoconstriction, and mucus production. Targeting of novel therapeutic agents to the lungs of patients with asthma may improve efficacy of treatments and minimize side effects. We previously demonstrated that Ca2+/calmodulin-dependent protein kinase (CaMKII) is expressed and activated in the bronchial epithelium of asthmatic patients. CaMKII inhibition in murine models of allergic asthma reduces key disease phenotypes, providing the rationale for targeted CaMKII inhibition as a potential therapeutic approach for asthma. Herein we developed a novel cationic nanoparticle (NP)-based system for delivery of the potent and specific CaMKII inhibitor peptide, CaMKIIN, to airways. CaMKIIN-loaded NPs abrogated the severity of allergic asthma in a murine model. These findings provide the basis for development of innovative, site-specific drug delivery therapies, particularly for treatment of pulmonary diseases such as asthma.
Details
- Title: Subtitle
- Cationic CaMKII Inhibiting Nanoparticles Prevent Allergic Asthma
- Creators
- Angie S Morris - University of IowaSara C Sebag - University of IowaJohn D Paschke - University of IowaAmaraporn Wongrakpanich - Department of Pharmacy, Faculty of PharmacyKareem Ebeid - University of IowaMark E Anderson - Department of MedicineIsabella M Grumbach - Iowa City Veterans Affairs Healthcare SystemAliasger K Salem - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Molecular pharmaceutics, Vol.14(6), pp.2166-2175
- DOI
- 10.1021/acs.molpharmaceut.7b00114
- PMID
- 28460526
- PMCID
- PMC5800301
- NLM abbreviation
- Mol Pharm
- ISSN
- 1543-8384
- eISSN
- 1543-8392
- Publisher
- American Chemical Society
- Grant note
- DOI: 10.13039/100000066, name: National Institute of Environmental Health Sciences, award: P30 ES005605, U01 ES027252 01; DOI: 10.13039/100000072, name: National Institute of Dental and Craniofacial Research; name: College of Pharmacy, University of Iowa; DOI: 10.13039/100015515, name: Roy J. and Lucille A. Carver College of Medicine, University of Iowa
- Language
- English
- Date published
- 06/05/2017
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Anatomy and Cell Biology; Pharmaceutical Sciences and Experimental Therapeutics; Cardiovascular Medicine; Radiation Oncology; Craniofacial Anomalies Research Center; Dental Research; Chemical and Biochemical Engineering; Internal Medicine
- Record Identifier
- 9984094337702771
Metrics
28 Record Views