Cationic nanoparticles enhance T cell tumor infiltration and antitumor immune responses to a melanoma vaccine

Rasheid Smith; Emad I Wafa; Sean M Geary; Kareem Ebeid; Suhaila O Alhaj-Suliman; Aliasger K Salem

doi:10.1126/sciadv.abk3150

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Cationic nanoparticles enhance T cell tumor infiltration and antitumor immune responses to a melanoma vaccine

Journal article

Open access

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Cationic nanoparticles enhance T cell tumor infiltration and antitumor immune responses to a melanoma vaccine

Rasheid Smith, Emad I Wafa, Sean M Geary, Kareem Ebeid, Suhaila O Alhaj-Suliman and Aliasger K Salem

Science advances, Vol.8(29), pp.eabk3150-eabk3150

07/22/2022

DOI: 10.1126/sciadv.abk3150

PMCID: PMC9299550

PMID: 35857851

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9299550View

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Abstract

In clinical settings, cancer vaccines as monotherapies have displayed limited success compared to other cancer immunotherapeutic treatments. Nanoscale formulations have the ability to increase the efficacy of cancer vaccines by combatting the immunosuppressive nature of the tumor microenvironment. Here, we have synthesized a previously unexplored cationic polymeric nanoparticle formulation using polyamidoamine dendrimers and poly(d,l-lactic-co-glycolic acid) that demonstrate adjuvant properties in vivo. Tumor-challenged mice vaccinated with an adenovirus-based cancer vaccine [encoding tumor-associated antigen (TAA)] and subsequently treated with this nanoparticulate formulation showed significant increases in TAA-specific T cells in the peripheral blood, reduced tumor burden, protection against tumor rechallenge, and a significant increase in median survival. An investigation into cell-based pathways suggests that administration of the nanoformulation at the site of the developing tumor may have created an inflammatory environment that attracted activated TAA-specific CD8+ T cells to the vicinity of the tumor, thus enhancing the efficacy of the vaccine.

Details

Title: Subtitle: Cationic nanoparticles enhance T cell tumor infiltration and antitumor immune responses to a melanoma vaccine
Creators: Rasheid Smith - University of Iowa
Emad I Wafa - University of Iowa
Sean M Geary - University of Iowa
Kareem Ebeid - University of Iowa
Suhaila O Alhaj-Suliman - University of Iowa
Aliasger K Salem - University of Iowa
Resource Type: Journal article
Publication Details: Science advances, Vol.8(29), pp.eabk3150-eabk3150
DOI: 10.1126/sciadv.abk3150
PMID: 35857851
PMCID: PMC9299550
NLM abbreviation: Sci Adv
eISSN: 2375-2548
Language: English
Date published: 07/22/2022
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Pharmaceutical Sciences and Experimental Therapeutics; Craniofacial Anomalies Research Center; Dental Research; Chemical and Biochemical Engineering
Record Identifier: 9984296966202771

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