Caudate nucleus volumes in stroke and vascular dementia

Jeffrey Chee Leong Looi; Vanessa Tatham; Rajeev Kumar; Jerome J. Maller; Ellen Millard; Wei Wen; Xiaohua Chen; Henry Brodaty; Perminder Sachdev

doi:10.1016/j.pscychresns.2009.04.002

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Caudate nucleus volumes in stroke and vascular dementia

Journal article

Peer reviewed

Caudate nucleus volumes in stroke and vascular dementia

Jeffrey Chee Leong Looi, Vanessa Tatham, Rajeev Kumar, Jerome J. Maller, Ellen Millard, Wei Wen, Xiaohua Chen, Henry Brodaty and Perminder Sachdev

Psychiatry research. Neuroimaging, Vol.174(1), pp.67-75

10/30/2009

DOI: 10.1016/j.pscychresns.2009.04.002

PMID: 19796921

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Abstract

We aimed to assess the volume of the nucleus caudatus as a neuroanatomical substrate of fronto-subcortical circuits, in stroke patients with/without dementia, and the relationship to potential determinants of neural circuit integrity such as white matter hyperintensities (WMH) and stroke volume Stroke only (Stroke) (n = 19) and stroke with Vascular Dementia (VaD) (n = 16) and healthy control (n = 20) subjects, matched on demographic variables. underwent extensive neuro psychiatric assessments and manual MRI-based volumetric measurements for intracranial area (ICA), stroke volume, and bilateral caudate volume WMH on MRI were quantified using an automated algorithm Multivariate analysis of covariance (controlling for age and ICA). revealed that across the three groups, caudate volumes were significantly different. There was a significant difference in bilateral caudate nucleus volume between subjects by diagnosis (Stroke. VaD, control). The control group was largest in overall mean volume of the diagnostic groups, followed by the Stroke group (86% of controls). and finally, the VaD group (72%). There was a partial correlation between total caudate volume and the total volume of deep WMH including periventricular regions and brainstem, controlling for ICA: and for total stroke volume. Stroke patients with VaD have smaller caudate nuclei compared to those without dementia and healthy controls, with the stroke-only patients being intermediate in their caudate volume status There was preliminary evidence of negative correlation of caudate volume with volume of deep WMH and total stroke volume, suggesting cerebrovascular disease contributes to caudate atrophy. which, in turn may disrupt fronto-subcortical circuits (C) 2009 Elsevier Ireland Ltd. All rights reserved.

Clinical Neurology

Life Sciences & Biomedicine

Neuroimaging

Neurosciences & Neurology

Psychiatry

Science & Technology

Details

Title: Subtitle: Caudate nucleus volumes in stroke and vascular dementia
Creators: Jeffrey Chee Leong Looi - ACT
Vanessa Tatham - Canberra Hospital
Rajeev Kumar - Australian National University
Jerome J. Maller - Monash Alfred Psychiatry Research centre
Ellen Millard - Australian National University
Wei Wen - Prince of Wales Hospital
Xiaohua Chen - Prince of Wales Hospital
Henry Brodaty - UNSW Sydney
Perminder Sachdev - Prince of Wales Hospital
Resource Type: Journal article
Publication Details: Psychiatry research. Neuroimaging, Vol.174(1), pp.67-75
DOI: 10.1016/j.pscychresns.2009.04.002
PMID: 19796921
NLM abbreviation: Psychiatry Res Neuroimaging
ISSN: 0925-4927
eISSN: 1872-7506
Publisher: Elsevier
Number of pages: 9
Grant note: National Health and Medical Research Council of Australia; National Health & Medical Research Council (NHMRC) of Australia
Language: English
Date published: 10/30/2009
Academic Unit: Radiology
Record Identifier: 9984848427802771

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