Journal article
Causes and consequences of aneuploidy in cancer
Nature reviews. Genetics, Vol.13(3), pp.189-203
2012
DOI: 10.1038/nrg3123
PMID: 22269907
Abstract
Genetic instability, which includes both numerical and structural chromosomal abnormalities, is a hallmark of cancer. Whereas the structural chromosome rearrangements have received substantial attention, the role of whole-chromosome aneuploidy in cancer is much less well-understood. Here we review recent progress in understanding the roles of whole-chromosome aneuploidy in cancer, including the mechanistic causes of aneuploidy, the cellular responses to chromosome gains or losses and how cells might adapt to tolerate these usually detrimental alterations. We also explore the role of aneuploidy in cellular transformation and discuss the possibility of developing aneuploidy-specific therapies.
Details
- Title: Subtitle
- Causes and consequences of aneuploidy in cancer
- Creators
- David J GORDON - Department of Pediatric Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, United StatesBenjamin RESIO - Department of Pediatric Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, United StatesDavid PELLMAN - Department of Pediatric Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, United States
- Resource Type
- Journal article
- Publication Details
- Nature reviews. Genetics, Vol.13(3), pp.189-203
- Publisher
- Nature Publishing Group
- DOI
- 10.1038/nrg3123
- PMID
- 22269907
- ISSN
- 1471-0056
- eISSN
- 1471-0064
- Language
- English
- Date published
- 2012
- Academic Unit
- Stead Family Department of Pediatrics; Hematology/Oncology
- Record Identifier
- 9984093474202771
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