Journal article
Causes and consequences of micronuclei
Current opinion in cell biology, Vol.70, pp.91-99
06/01/2021
DOI: 10.1016/j.ceb.2021.01.004
PMID: 33610905
Abstract
Micronuclei are small membrane-bounded compartments with a DNA content encapsulated by a nuclear envelope and spatially separated from the primary nucleus. Micronuclei have long been linked to chromosome instability, genome rearrangements, and mutagenesis. They are frequently found in cancers, during senescence, and after genotoxic stress. Compromised integrity of the micronuclear envelope delays or disrupts DNA replication, inhibits DNA repair, and exposes micronuclear DNA directly to cytoplasm. Micronuclei play a central role in tumorigenesis, with micronuclear DNA being a source of complex genome rearrangements (including chromothripsis) and promoting a cyclic GMP-AMP synthase (cGAS)-mediated cellular immune response that may contribute to cancer metastasis. Here, we discuss recent findings on how micronuclei are generated, what the consequences are, and what cellular mechanisms can be applied to protect against micronucleation.
Details
- Title: Subtitle
- Causes and consequences of micronuclei
- Creators
- Ksenia Krupina - University of California San DiegoAlexander Goginashvili - Ludwig Cancer ResearchDon W Cleveland - Ludwig Cancer Research
- Resource Type
- Journal article
- Publication Details
- Current opinion in cell biology, Vol.70, pp.91-99
- DOI
- 10.1016/j.ceb.2021.01.004
- PMID
- 33610905
- NLM abbreviation
- Curr Opin Cell Biol
- ISSN
- 0955-0674
- eISSN
- 1879-0410
- Publisher
- Current Biology Ltd
- Number of pages
- 9
- Grant note
- R35-GM122476 / US National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Ludwig Institute for Cancer Research
- Language
- English
- Date published
- 06/01/2021
- Academic Unit
- Biochemistry and Molecular Biology
- Record Identifier
- 9985134035702771
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