Cbl-b: Roles in T Cell Tolerance, Proallergic T Cell Development, and Cancer Immunity

Jian Zhang; Qingjun Liu; Wallace Y Langdon

doi:10.14800/ics.146

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Cbl-b: Roles in T Cell Tolerance, Proallergic T Cell Development, and Cancer Immunity

Journal article

Open access

Peer reviewed

Cbl-b: Roles in T Cell Tolerance, Proallergic T Cell Development, and Cancer Immunity

Jian Zhang, Qingjun Liu and Wallace Y Langdon

Inflammation and cell signaling, Vol.1(4), e146

2014

DOI: 10.14800/ics.146

PMCID: PMC4465365

PMID: 26082933

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Abstract

Cbl-b is a member of the Cbl family of RING finger E3 ubiquitin ligases and polymorphisms and mutations in Cbl-b are associated with several autoimmune/inflammatory diseases in humans. Furthermore, gene targeting experiments in mice have provided proof of the in vivo effects of Cbl-b on T cell function and its involvement with these diseases. This brief review updates our understanding of Cbl-b in T cell tolerance, proallergic T cell development, and cancer immunity in light of the most recent advances, and their impact on autoimmune-/inflammatory diseases and cancer immunotherapy.

Asthma

Autoimmunity

cancer

Cbl-b

NK cells

proallergic T cells

T cell tolerance

Details

Title: Subtitle: Cbl-b: Roles in T Cell Tolerance, Proallergic T Cell Development, and Cancer Immunity
Creators: Jian Zhang - University of Iowa, Pathology
Qingjun Liu - The Ohio State University
Wallace Y Langdon - The University of Western Australia
Resource Type: Journal article
Publication Details: Inflammation and cell signaling, Vol.1(4), e146
DOI: 10.14800/ics.146
PMID: 26082933
PMCID: PMC4465365
NLM abbreviation: Inflamm Cell Signal
ISSN: 2330-7803
eISSN: 2330-7803
Language: English
Date published: 2014
Academic Unit: Pathology
Record Identifier: 9984195952802771

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