Journal article
Cefazolin embedded biodegradable polypeptide nanofilms promising for infection prevention: A preliminary study on cell responses
Journal of orthopaedic research, Vol.28(8), pp.992-999
08/2010
DOI: 10.1002/jor.21115
PMCID: PMC3699871
PMID: 20162715
Abstract
Implant-associated infection is a serious complication in orthopedic surgery, and endowing implant surfaces with antibacterial properties could be one of the most promising approaches for preventing such infection. In this study, we developed cefazolin loaded biodegradable polypeptide multilayer nanofilms on orthopedic implants. We found that the amount of cefazolin released could be tuned. A high local concentration of cefazolin was achieved within the first a few hours and therefore may inhibit bacterial colonization in the critical postimplantation period. The developed cefazolin loaded nanofilms showed their in vitro efficacy against Staphylococcus aureus; the more antibiotics loaded, the longer the nanocoated implant had antibacterial properties. More interestingly, antibiotic-loaded polypeptide multilayer nanofilms also improved osteoblast bioactivity including cell viability and proliferation. These findings suggested that biodegradable polypeptide multilayernanofilms as antibiotic carriers at the implant/tissue interface are compatible withhumancells such as osteoblasts and bactericidal to bacteria such as S. aureus. These characteristics could be promising for preventing implant-associated infection and potentially improving bone healing. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.
Details
- Title: Subtitle
- Cefazolin embedded biodegradable polypeptide nanofilms promising for infection prevention: A preliminary study on cell responses
- Creators
- Hongshuai Li - West Virginia UniversityHeather Ogle - West Virginia UniversityBingbing Jiang - West Virginia UniversityMichael Hagar - West Virginia UniversityBingyun Li - WVNano Initiative, Morgantown, West Virginia 26506
- Resource Type
- Journal article
- Publication Details
- Journal of orthopaedic research, Vol.28(8), pp.992-999
- DOI
- 10.1002/jor.21115
- PMID
- 20162715
- PMCID
- PMC3699871
- NLM abbreviation
- J Orthop Res
- ISSN
- 0736-0266
- eISSN
- 1554-527X
- Publisher
- Wiley Subscription Services, Inc., A Wiley Company
- Number of pages
- 8
- Language
- English
- Date published
- 08/2010
- Academic Unit
- Orthopedics and Rehabilitation; Radiation Oncology
- Record Identifier
- 9984304711502771
Metrics
11 Record Views