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Cefepime MIC as a Predictor of the Extended-Spectrum β-Lactamase Type in Klebsiella pneumoniae, Taiwan
Journal article   Open access   Peer reviewed

Cefepime MIC as a Predictor of the Extended-Spectrum β-Lactamase Type in Klebsiella pneumoniae, Taiwan

Wen Leong Yu, Michael A Pfaller, Patricia L Winokur and Ronald N Jones
Emerging infectious diseases, Vol.8(5), pp.522-524
05/2002
DOI: 10.3201/eid0805.010346
PMCID: PMC2732501
PMID: 11996691
url
https://doi.org/10.3201/eid0805.010346View
Published (Version of record) Open Access

Abstract

To guide selection of carbapenems or fourth-generation cephalosporins as therapy, 110 Klebsiella pneumoniae isolates with extended-spectrum β-lactamases from Taiwan were characterized by phenotypic (MICs), molecular, and chemical methods. MIC patterns of ceftazidime and cefepime clearly differentiate strains treatable by cefepime and those capable of efficiently hydrolyzing available cephalosporins (CTX-M series and SHV-types). Continued use of cefepime appears to be a treatment option in cases for which MIC results are available and interpreted by the criteria presented.
Taiwan extended-spectrum β-lactamases Dispatch cefepime CTX-M enzymes carbapenems Klebsiella pneumoniae

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