Journal article
Ceftriaxone versus ampicillin/sulbactam for the treatment of aspiration-associated pneumonia in adults
Journal of comparative effectiveness research, Vol.8(15), pp.1275-1284
11/01/2019
DOI: 10.2217/cer-2019-0041
PMID: 31736321
Abstract
Aim: To compare hospital mortality in patients with aspiration-associated pneumonia treated with ceftriaxone (CTRX) and in those treated with ampicillin/sulbactam (ABPC/SBT). Methods: From a Japanese multicentre observational study cohort of patients with pneumonia, those diagnosed with pneumonia and having at least one aspiration-related risk factor were selected. Propensity score-matching analysis was used to balance baseline characteristics of the participants and compare hospital mortality of patients treated with CTRX and those treated with ABPC/SBT. Results: Hospital mortality did not significantly differ between patients treated with CTRX and those treated with ABPC/SBT (6.6 vs 10.7%, risk difference -4.0, 95% CI [-9.4, 1.3]; p = 0.143). Conclusion: Further studies are needed to compare CTRX and ABPC/SBT treatments in patients with aspiration-associated pneumonia.
Details
- Title: Subtitle
- Ceftriaxone versus ampicillin/sulbactam for the treatment of aspiration-associated pneumonia in adults
- Creators
- Shinya Hasegawa - Tokyo Metropolitan Tama Medical CenterAtsushi Shiraishi - Kameda Medical CenterMakito Yaegashi - Kameda Medical CenterNaoto Hosokawa - Kameda Medical CenterKonosuke Morimoto - Nagasaki UniversityTakahiro Mori - University of Tsukuba
- Resource Type
- Journal article
- Publication Details
- Journal of comparative effectiveness research, Vol.8(15), pp.1275-1284
- DOI
- 10.2217/cer-2019-0041
- PMID
- 31736321
- ISSN
- 2042-6305
- eISSN
- 2042-6313
- Publisher
- Future Medicine Ltd
- Number of pages
- 10
- Grant note
- Pfizer, Inc.; Pfizer
- Language
- English
- Date published
- 11/01/2019
- Academic Unit
- Internal Medicine
- Record Identifier
- 9985177940902771
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