Journal article
Celecoxib Versus Placebo in Tonsillectomy: A Prospective, Randomized, Double-Blind Placebo-Controlled Trial
Annals of otology, rhinology & laryngology, Vol.125(10), pp.785-800
10/01/2016
DOI: 10.1177/0003489416654707
PMID: 27357971
Abstract
Objectives: Celecoxib is a cyclooxygenase-2-specific inhibitor indicated to treat acute pain and pain secondary to osteoarthritis and rheumatoid arthritis. Surgical models of acute pain have demonstrated superior pain relief to placebo. The objective of this study was to test the safety and efficacy of celecoxib for pain relief after tonsillectomy compared to placebo.
Methods: Adult subjects were randomized to 200 mg celecoxib versus placebo with a loading dose the night before surgery then twice daily for 10 days. Subjects were instructed to supplement the study drug with hydrocodone/acetaminophen liquid or acetaminophen for pain as needed. Subjects completed a daily diary regarding their pain, nausea, vomiting, diet, and activity.
Results: Seventeen subjects enrolled. Intraoperative blood loss was similar between groups, and no subject had postoperative bleeding. Three patients returned to the emergency department for treatment, and 2 patients could not complete the diaries, all in the placebo group. Subjects in the placebo group required statistically significant (P < .05) higher doses of narcotic and acetaminophen to control pain. Pain and diet rating scores were slightly better in the celecoxib group compared to placebo.
Conclusions: In this small cohort, celecoxib reduced postoperative narcotic and acetaminophen requirements compared to placebo without complications.
Details
- Title: Subtitle
- Celecoxib Versus Placebo in Tonsillectomy: A Prospective, Randomized, Double-Blind Placebo-Controlled Trial
- Creators
- Douglas J. Van Daele - University of IowaKellie L. Bodeker - University of IowaDouglas K. Trask - Cleveland Clinic
- Resource Type
- Journal article
- Publication Details
- Annals of otology, rhinology & laryngology, Vol.125(10), pp.785-800
- Publisher
- Sage
- DOI
- 10.1177/0003489416654707
- PMID
- 27357971
- ISSN
- 0003-4894
- eISSN
- 1943-572X
- Number of pages
- 16
- Grant note
- WS297645 / Pfizer
- Language
- English
- Date published
- 10/01/2016
- Academic Unit
- Radiation Oncology; Medicine Administration; Otolaryngology
- Record Identifier
- 9984311444602771
Metrics
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