Journal article
Cell Permeable Iron Chelators as Potential Cancer Chemotherapeutic Agents
Cancer investigation, Vol.23(8), pp.683-691
01/01/2005
DOI: 10.1080/07357900500359976
PMID: 16377587
Abstract
Iron is an essential micronutrient for the growth and function of all cells. It is, therefore, an attractive target for chemotherapeutic compounds. Numerous studies in vitro and in vivo provide evidence that iron chelators may be effective antitumor agents. Lipophilic iron chelators that are readily cell permeable and can bind intracellular iron stores may selectively kill cancer cells without damaging normal cells. In this review we discuss the role of iron in cellular processes and how these processes differ between normal and neoplastic cells. We also review the effects on normal and cancer cell growth of several lipophilic iron chelators.
Details
- Title: Subtitle
- Cell Permeable Iron Chelators as Potential Cancer Chemotherapeutic Agents
- Creators
- Paula M. B. Pahl - University of Colorado HealthLawrence D. Horwitz - University of Colorado Health
- Resource Type
- Journal article
- Publication Details
- Cancer investigation, Vol.23(8), pp.683-691
- Publisher
- Informa UK Ltd
- DOI
- 10.1080/07357900500359976
- PMID
- 16377587
- ISSN
- 0735-7907
- eISSN
- 1532-4192
- Language
- English
- Date published
- 01/01/2005
- Academic Unit
- Cardiovascular Medicine; Internal Medicine
- Record Identifier
- 9984656606902771
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