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Cell adhesion molecules in synapse formation
Journal article   Open access   Peer reviewed

Cell adhesion molecules in synapse formation

Philip Washbourne, Alexander Dityatev, Peter Scheiffele, Thomas Biederer, Joshua A Weiner, Karen S Christopherson and Alaa El-Husseini
The Journal of neuroscience, Vol.24(42), pp.9244-9249
10/20/2004
DOI: 10.1523/JNEUROSCI.3339-04.2004
PMCID: PMC6730099
PMID: 15496659
url
https://doi.org/10.1523/JNEUROSCI.3339-04.2004View
Published (Version of record) Open Access

Abstract

Neuronal transmission relies on signals transmitted through a vast array of excitatory and inhibitory neuronal synaptic connections. How do axons communicate with dendrites to build synapses, and what molecules regulate this interaction? There is a wealth of evidence suggesting that cell adhesion molecules (CAMs) provide much of the information required for synapse formation. This review highlights the molecular mechanisms used by CAMs to regulate presynaptic and postsynaptic differentiation.
Axons - physiology Animals Cell Adhesion Molecules - physiology Synapses - physiology Dendrites - physiology Humans

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