Cell and receptor requirements for streptococcal pyrogenic exotoxin T-cell mitogenicity

B A Leonard; P K Lee; M K Jenkins; P M Schlievert

doi:10.1128/IAI.59.3.1210-1214.1991

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Cell and receptor requirements for streptococcal pyrogenic exotoxin T-cell mitogenicity

Journal article

Open access

Peer reviewed

Cell and receptor requirements for streptococcal pyrogenic exotoxin T-cell mitogenicity

B A Leonard, P K Lee, M K Jenkins and P M Schlievert

Infection and immunity, Vol.59(3), pp.1210-1214

03/1991

DOI: 10.1128/IAI.59.3.1210-1214.1991

PMCID: PMC258393

PMID: 1997426

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Abstract

Streptococcal pyrogenic exotoxins (SPEs) A, B, and C, like other members of the pyrogenic toxin family, are able to cause toxic shock-like syndromes. One of the major properties of these toxins is the ability to induce T-cell proliferation. Characterization of T cell mitogenicity associated with SPEs A, B, and C was undertaken. SPEs A, B, and C were mitogenic for C57BL10/SnJ and BALB/cWAT T cells, with activities differing in intensity depending on the mouse strain and toxin employed. SPE-induced, T-cell-proliferative activity was dependent on class II major histocompatibility complex molecules expressed on antigen-presenting cells. The abilities of SPEs A, B, and C to preferentially stimulate murine cells with certain T-cell receptor V beta s were investigated by fluorescence-activated cell sorter analysis. SPE A preferentially activated T cells expressing V beta 8 but not V beta 3, 6, or 11, while SPEs B and C preferentially stimulated T cells which did not express any of the tested V beta s.

Details

Title: Subtitle: Cell and receptor requirements for streptococcal pyrogenic exotoxin T-cell mitogenicity
Creators: B A Leonard - Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455
P K Lee - Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455
M K Jenkins - Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455
P M Schlievert - Department of Microbiology, University of Minnesota Medical School, Minneapolis 55455
Resource Type: Journal article
Publication Details: Infection and immunity, Vol.59(3), pp.1210-1214
DOI: 10.1128/IAI.59.3.1210-1214.1991
PMID: 1997426
PMCID: PMC258393
ISSN: 0019-9567
eISSN: 1098-5522
Language: English
Date published: 03/1991
Academic Unit: Microbiology and Immunology; Internal Medicine
Record Identifier: 9984001118702771

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