Cell cycle: Molecular targets for diagnosis and therapy: Tumor suppressor genes and cell cycle progression in cancer

Antonio Giordano; Youcef M. Rustum; Charles E. Wenner

doi:10.1002/(SICI)1097-4644(19980701)70:1<1::AID-JCB1>3.0.CO;2-T

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Cell cycle: Molecular targets for diagnosis and therapy: Tumor suppressor genes and cell cycle progression in cancer

Journal article

Open access

Peer reviewed

Cell cycle: Molecular targets for diagnosis and therapy: Tumor suppressor genes and cell cycle progression in cancer

Antonio Giordano, Youcef M. Rustum and Charles E. Wenner

Journal of cellular biochemistry, Vol.70(1), pp.1-7

07/01/1998

DOI: 10.1002/(SICI)1097-4644(19980701)70:1<1::AID-JCB1>3.0.CO;2-T

PMID: 9632102

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https://doi.org/10.1002/(SICI)1097-4644(19980701)70:1<1::AID-JCB1>3.0.CO;2-TView

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Abstract

A significant portion of published literature is dedicated to describing the cloning and the characterization of proteins involved in the progression of the cell cycle, which govern cell growth both in cancer and normal ontogenesis. With this abundance of information, the cascading pathways of molecular events that occur in the cell cycle are proving to be exceedingly complicated. The purpose of this conference was to attract the leading clinical and basic science investigators in the growth control field with a final goal to determine how this current wealth of knowledge can be used to impact upon patient care and management by the design of novel adjuvant therapeutics specifically targeted at tumor cells and the identification of molecular diagnostic and/or prognostic markers in an efficient and cost effective manner.

Apoptosis

Leukemia

colon cancer

E2F

p53

pRb2/p130

protein phosphatases

retinoblastoma

transcriptional control

Details

Title: Subtitle: Cell cycle: Molecular targets for diagnosis and therapy: Tumor suppressor genes and cell cycle progression in cancer
Creators: Antonio Giordano - Sbarro Institute for Cancer Research and Molecular Medicine and Department of Pathology, Jefferson Medical College, Philadelphia, Pennsylvania 19107, USA.
Youcef M. Rustum - Roswell Park Cancer Institute
Charles E. Wenner - Roswell Park Cancer Institute
Resource Type: Journal article
Publication Details: Journal of cellular biochemistry, Vol.70(1), pp.1-7
Publisher: Wiley Subscription Services, Inc., A Wiley Company
DOI: 10.1002/(SICI)1097-4644(19980701)70:1<1::AID-JCB1>3.0.CO;2-T
PMID: 9632102
ISSN: 0730-2312
eISSN: 1097-4644
Number of pages: 7
Language: English
Date published: 07/01/1998
Academic Unit: Hematology, Oncology, and Blood & Marrow Transplantation; Internal Medicine
Record Identifier: 9984360044402771

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