Cell cycle progression score predicts metastatic progression of clear cell renal cell carcinoma after resection

Eric J Askeland; Vincent A Chehval; Ryan W Askeland; Placede G Fosso; Zaina Sangale; Nafei Xu; Saradha Rajamani; Steven Stone; James A Brown

doi:10.3233/CBM-150530

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Cell cycle progression score predicts metastatic progression of clear cell renal cell carcinoma after resection

Journal article

Open access

Peer reviewed

Cell cycle progression score predicts metastatic progression of clear cell renal cell carcinoma after resection

Eric J Askeland, Vincent A Chehval, Ryan W Askeland, Placede G Fosso, Zaina Sangale, Nafei Xu, Saradha Rajamani, Steven Stone and James A Brown

Cancer biomarkers : section A of Disease markers, Vol.15(6), pp.861-867

2015

DOI: 10.3233/CBM-150530

PMID: 26406412

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https://doi.org/10.3233/CBM-150530View

Published (Version of record) Open Access

Abstract

The outcome of surgically resected, apparently localized, clear cell renal carcinoma (ccRCC) is uncertain. To evaluate if cell cycle progression (CCP) gene expression can predict future metastasis. Pathologic T2a-T3b tumors at University of Iowa were reviewed. Patients with known or suspected metastasis, lymph node involvement or who received neoadjuvant or adjuvant radiation, chemotherapy or immunotherapy were excluded. Case and control cohorts were defined as those who did or did not develop metastatic disease within 5 years. Measured levels of 31 cell cycle genes and 15 control genes from the tumor were calculated as a CCP score. Additionally, gene expression data for a separate ccRCC cohort was downloaded from The Cancer Genome Atlas (TCGA). Univariate analysis of 26 cases and 38 controls revealed that the CCP score predicted progression to metastasis (OR 2.65, p = 0.0091). In multivariate logistic regression modeling, CCP expression remained a significant independent predictor for progression (p = 0.026). The CCP score was also significantly associated with distant metastasis in the TCGA renal cancer cohort in both univariate (p = 1.0 × 10-9) and multivariate (p = 5.6 × 10-3) analysis. The CCP score has prognostic value in predicting metastatic progression after resection of organ-confined ccRCC.

Cell Cycle - genetics

Kidney Neoplasms - genetics

Prognosis

Follow-Up Studies

Neoplasm Invasiveness

Humans

Middle Aged

Carcinoma, Renal Cell - genetics

Carcinoma, Renal Cell - surgery

Male

Lymphatic Metastasis

Case-Control Studies

Kidney Neoplasms - surgery

Carcinoma, Renal Cell - secondary

Cell Cycle Proteins - genetics

Female

Kidney Neoplasms - pathology

Biomarkers, Tumor - genetics

Retrospective Studies

Neoplasm Staging

Real-Time Polymerase Chain Reaction

Details

Title: Subtitle: Cell cycle progression score predicts metastatic progression of clear cell renal cell carcinoma after resection
Creators: Eric J Askeland - Department of Urology, University of Iowa, IA, USA
Vincent A Chehval - Department of Urology, University of Iowa, IA, USA
Ryan W Askeland - Department of Pathology, University of Iowa, IA, USA
Placede G Fosso - Myriad Genetics, University of Iowa, IA, USA
Zaina Sangale - Myriad Genetics, University of Iowa, IA, USA
Nafei Xu - Myriad Genetics, University of Iowa, IA, USA
Saradha Rajamani - Myriad Genetics, University of Iowa, IA, USA
Steven Stone - Myriad Genetics, University of Iowa, IA, USA
James A Brown - Department of Urology, University of Iowa, IA, USA
Resource Type: Journal article
Publication Details: Cancer biomarkers : section A of Disease markers, Vol.15(6), pp.861-867
Publisher: Netherlands
DOI: 10.3233/CBM-150530
PMID: 26406412
ISSN: 1574-0153
eISSN: 1875-8592
Language: English
Date published: 2015
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Urology
Record Identifier: 9984051724502771

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