Cell receptor-independent infection by a neurotropic murine coronavirus

Thomas M Gallagher; Michael J Buchmeier; Stanley Perlman

doi:10.1016/0042-6822(92)90223-C

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Cell receptor-independent infection by a neurotropic murine coronavirus

Journal article

Open access

Peer reviewed

Cell receptor-independent infection by a neurotropic murine coronavirus

Thomas M Gallagher, Michael J Buchmeier and Stanley Perlman

Virology, Vol.191(1), pp.517-522

11/1992

DOI: 10.1016/0042-6822(92)90223-C

PMCID: PMC7131763

PMID: 1413526

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Abstract

The cellular receptors for a coronavirus, mouse hepatitis virus (MHV), have been recently identified as one or more members of the carcinoembryonic antigen (CEA) family. The neurotropic JHM strain of MHV (MHV-JHM) possesses a highly fusogenic surface (S) glycoprotein. This protein is now shown to promote the spread of MHV into cells lacking the specific CEA-related MHV receptor. Resistant cells are recruited into MHV-induced syncytium with consequent production of progeny virus. Cell-to-cell spread of virus via membrane fusion without the requirement for specific cell surface receptor offers a novel way for virus to spread within infected hosts.

Rabbits

Cricetinae

Receptors, Virus - metabolism

Humans

Cells, Cultured

Giant Cells - microbiology

Spike Glycoprotein, Coronavirus

Animals

Virus Replication

Viral Envelope Proteins - metabolism

Mice

Membrane Glycoproteins

Coronaviridae - physiology

Details

Title: Subtitle: Cell receptor-independent infection by a neurotropic murine coronavirus
Creators: Thomas M Gallagher - Department of Neuropharmacology, Scripps Research Institute, La Jolla, California 92037
Michael J Buchmeier
Stanley Perlman
Resource Type: Journal article
Publication Details: Virology, Vol.191(1), pp.517-522
DOI: 10.1016/0042-6822(92)90223-C
PMID: 1413526
PMCID: PMC7131763
NLM abbreviation: Virology
ISSN: 0042-6822
eISSN: 1096-0341
Publisher: United States
Grant note: NS 12428 / NINDS NIH HHS NS22347 / NINDS NIH HHS NS24401 / NINDS NIH HHS
Language: English
Date published: 11/1992
Academic Unit: Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
Record Identifier: 9983777474402771

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