Journal article
Cell surface recycling in yeast: mechanisms and machineries
Biochemical Society transactions, Vol.44(2), pp.474-478
04/15/2016
DOI: 10.1042/BST20150263
PMCID: PMC5019169
PMID: 27068957
Abstract
Sorting internalized proteins and lipids back to the cell surface controls the supply of molecules throughout the cell and regulates integral membrane protein activity at the surface. One central process in mammalian cells is the transit of cargo from endosomes back to the plasma membrane (PM) directly, along a route that bypasses retrograde movement to the Golgi. Despite recognition of this pathway for decades we are only beginning to understand the machinery controlling this overall process. The budding yeast Saccharomyces cerevisiae, a stalwart genetic system, has been routinely used to identify fundamental proteins and their modes of action in conserved trafficking pathways. However, the study of cell surface recycling from endosomes in yeast is hampered by difficulties that obscure visualization of the pathway. Here we briefly discuss how recycling is likely a more prevalent process in yeast than is widely appreciated and how tools might be built to better study the pathway.
Details
- Title: Subtitle
- Cell surface recycling in yeast: mechanisms and machineries
- Creators
- Chris MacDonald - University of IowaRobert C. Piper - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Biochemical Society transactions, Vol.44(2), pp.474-478
- Publisher
- Portland Press Ltd
- DOI
- 10.1042/BST20150263
- PMID
- 27068957
- PMCID
- PMC5019169
- ISSN
- 0300-5127
- eISSN
- 1470-8752
- Number of pages
- 5
- Grant note
- NIHRO1-GM058202 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01GM058202 / NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of General Medical Sciences (NIGMS) 15POST-22980010 / American Heart Association
- Language
- English
- Date published
- 04/15/2016
- Academic Unit
- Molecular Physiology and Biophysics; Medicine Administration; Internal Medicine
- Record Identifier
- 9984297493502771
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