Journal article
Cellular and Humoral Immunity to Varicella Zoster Virus Glycoproteins in Immune and Susceptible Human Subjects
The Journal of infectious diseases, Vol.160(6), pp.919-928
12/1989
DOI: 10.1093/infdis/160.6.919
PMID: 2555419
Abstract
To further delineate the immune responses that protect against serious primary varicella zoster virus (VZV) infection and inhibit viral reactivation, antibody responses and T lymphocyte reactivity to three major VZV glycoproteins, gpI, gpII, and gpIII, were studied. Individual viral glycoproteins were purified using murine monoclonal antibodies. Cellular immunity was measured by lymphocyte proliferation. Antibody responses were tested in enzyme-linked immunosorbent assays. Individual glycoproteins induced VZV-specific proliferation by mononuclear cells from 15 of 20 immune subjects. Serologic responses to the VZV glycoproteins occurred in 16 of 20 immune subjects. Of note, gpII served as a potent T and B cell antigen during both acute infection and convalescence. Cell-mediated responses to the glycoprotein antigens represented proliferation by T lymphocytes and required antigen presentation by adherent mononuclear cells. These findings indicate that virally encoded glycoproteins contain epitopes that stimulate VZV-specific cellular and humoral immune responses.
Details
- Title: Subtitle
- Cellular and Humoral Immunity to Varicella Zoster Virus Glycoproteins in Immune and Susceptible Human Subjects
- Creators
- Roger H Giller - Departments of Pediatrics and Microbiology, University of Iowa College of Medicine, Iowa CityStanley Winistorfer - Departments of Pediatrics and Microbiology, University of Iowa College of Medicine, Iowa CityCharles Grose - Departments of Pediatrics and Microbiology, University of Iowa College of Medicine, Iowa City
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.160(6), pp.919-928
- Publisher
- The University of Chicago Press
- DOI
- 10.1093/infdis/160.6.919
- PMID
- 2555419
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Language
- English
- Date published
- 12/1989
- Academic Unit
- Molecular Physiology and Biophysics; Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
- Record Identifier
- 9984093475602771
Metrics
23 Record Views