Journal article
Cellular interactions and bone healing responses to a novel porous tricalcium phosphate bone graft material
Orthopedics (Thorofare, N.J.), Vol.27(1), pp.s167-s173
2004
DOI: 10.3928/0147-7447-20040102-18
PMID: 14763552
Abstract
The use of a porous tricalcium phosphate bone void filler (Cellplex TCP, Wright Medical Technology, Ine, Arlington, Tenn) as an alternative to autograft in bone grafting was studied in benchtop, in vitro cell culture, and in vivo preclinical studies. The experimental design included material property quantification, scaffold seeding with mesenchymal stem cells, and implantation in a rabbit segmental defect model. Measured material properties denoted appropriate composition, porosity, and strengths as compared to the literature. Fluid uptake studies and mesenchymal stem cell affinity revealed the scaffold's capabilities as a suitable host for osteoprogenitor cells. In a 1 -cm rabbit diaphyseal segmental defect stabilized with an external fixator, tricalcium phosphate was compared to intact autograft, crushed autograft, and open defects. Torsional strengths and stiffnesses of tricalcium phosphatetreated tibia were greater than or equivalent to both intact and crushed autograft controls. Tricalcium phosphate pores exhibited complete bony infiltration histologically. Collectively, the tricalcium phosphate material properties, cell seeding capabilities, and in vivo biological responses give evidence of this implant's functionality as a potential alternative for autograft.
Details
- Title: Subtitle
- Cellular interactions and bone healing responses to a novel porous tricalcium phosphate bone graft material
- Creators
- Douglas C FREDERICKS - Bone Healing Research Laboratory, University of Iowa College of Medicine, Iowa City, Iowa, United StatesJohn A BOBST - Bone Healing Research Laboratory, University of Iowa College of Medicine, Iowa City, Iowa, United StatesEmily B PETERSEN - Bone Healing Research Laboratory, University of Iowa College of Medicine, Iowa City, Iowa, United StatesJames V NEPOLA - Bone Healing Research Laboratory, University of Iowa College of Medicine, Iowa City, Iowa, United StatesJames E DENNIS - Case Western Reserve University, Skeletal Research Center, Cleveland, Ohio, United StatesArnold I CAPLAN - Case Western Reserve University, Skeletal Research Center, Cleveland, Ohio, United StatesAnn V BURGESS - Wright Medical Technology, Inc, Arlington, Tenn, United StatesRobyn J OVERBY - Wright Medical Technology, Inc, Arlington, Tenn, United StatesOlaf H SCHULZ - Wright Medical Technology, Inc, Arlington, Tenn, United States
- Resource Type
- Journal article
- Publication Details
- Orthopedics (Thorofare, N.J.), Vol.27(1), pp.s167-s173
- DOI
- 10.3928/0147-7447-20040102-18
- PMID
- 14763552
- NLM abbreviation
- Orthopedics
- ISSN
- 0147-7447
- eISSN
- 1938-2367
- Publisher
- Slack; Thorofare, NJ
- Language
- English
- Date published
- 2004
- Academic Unit
- Orthopedics and Rehabilitation; Craniofacial Anomalies Research Center
- Record Identifier
- 9984040577302771
Metrics
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