Journal article
Cellular mitosis predicts vessel stability in a mechanochemical model of sprouting angiogenesis
Biomechanics and modeling in mechanobiology, Vol.20(3), pp.1195-1208
06/01/2021
DOI: 10.1007/s10237-021-01442-8
PMCID: PMC8274398
PMID: 33715101
Abstract
Angiogenesis, the formation of new vessels, occurs in both developmental and pathological contexts. Prior research has investigated vessel formation to identify cellular phenotypes and dynamics associated with angiogenic disease. One major family of proteins involved in angiogenesis are the Rho GTPases, which govern function related to cellular elongation, migration, and proliferation. Using a mechanochemical model coupling Rho GTPase activity and cellular and intercellular mechanics, we investigate the role of cellular mitosis on sprouting angiogenesis. Mitosis-GTPase synchronization was not a strong predictor of GTPase and thus vessel signaling instability, whereas the location of mitotic events was predicted to alter GTPase cycling instabilities. Our model predicts that middle stalk cells undergoing mitosis introduce irregular dynamics in GTPase cycling and may provide a source of aberrant angiogenesis. We also find that cellular and junctional tension exhibit spatial heterogeneity through the vessel, and that tension feedback, specifically in stalk cells, tends to increase the maximum forces generated in the vessel.
Details
- Title: Subtitle
- Cellular mitosis predicts vessel stability in a mechanochemical model of sprouting angiogenesis
- Creators
- Patrick A. Link - Virginia Commonwealth UniversityRebecca L. Heise - Virginia Commonwealth UniversitySeth H. Weinberg - The Ohio State University
- Resource Type
- Journal article
- Publication Details
- Biomechanics and modeling in mechanobiology, Vol.20(3), pp.1195-1208
- DOI
- 10.1007/s10237-021-01442-8
- PMID
- 33715101
- PMCID
- PMC8274398
- NLM abbreviation
- Biomech Model Mechanobiol
- ISSN
- 1617-7959
- eISSN
- 1617-7940
- Publisher
- Springer Nature
- Number of pages
- 14
- Grant note
- CMMI-1351162 / National Science Foundation (NSF) R01GM122855 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA 2016207025 / National Science Foundation Graduate Research Fellowship; National Science Foundation (NSF)
- Language
- English
- Date published
- 06/01/2021
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Craniofacial Anomalies Research Center
- Record Identifier
- 9984948140102771
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