Cellular stress mechanisms of prenatal maternal stress: Heat shock factors and oxidative stress

Jonathan Dowell; Benjamin A Elser; Rachel E Schroeder; Hanna E Stevens

doi:10.1016/j.neulet.2019.134368

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Cellular stress mechanisms of prenatal maternal stress: Heat shock factors and oxidative stress

Journal article

Peer reviewed

Cellular stress mechanisms of prenatal maternal stress: Heat shock factors and oxidative stress

Jonathan Dowell, Benjamin A Elser, Rachel E Schroeder and Hanna E Stevens

Neuroscience letters, Vol.709, pp.134368-134368

09/14/2019

DOI: 10.1016/j.neulet.2019.134368

PMID: 31299286

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https://www.ncbi.nlm.nih.gov/pmc/articles/7053403View

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Abstract

•Prenatal maternal stress increases risk for neuropsychiatric disorders in offspring.•Heat shock factor and oxidative stress mechanisms are implicated in prenatal stress.•These cellular stress mechanisms may be targets for neuropsychiatric interventions. Development of the brain prenatally is affected by maternal experience and exposure. Prenatal maternal psychological stress changes brain development and results in increased risk for neuropsychiatric disorders. In this review, multiple levels of prenatal stress mechanisms (offspring brain, placenta, and maternal physiology) are discussed and their intersection with cellular stress mechanisms explicated. Heat shock factors and oxidative stress are closely related to each other and converge with the inflammation, hormones, and cellular development that have been more deeply explored as the basis of prenatal stress risk. Increasing evidence implicates cellular stress mechanisms in neuropsychiatric disorders associated with prenatal stress including affective disorders, schizophrenia, and child-onset psychiatric disorders. Heat shock factors and oxidative stress also have links with the mechanisms involved in other kinds of prenatal stress including external exposures such as environmental toxicants and internal disruptions such as preeclampsia. Integrative understanding of developmental neurobiology with these cellular and physiological mechanisms is necessary to reduce risks and promote healthy brain development.

Oxidative Stress

Neurodevelopment

Embryonic brain

Neuropsychiatric disorders

Prenatal stress

Heat shock

Details

Title: Subtitle: Cellular stress mechanisms of prenatal maternal stress: Heat shock factors and oxidative stress
Creators: Jonathan Dowell - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA
Benjamin A Elser - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA
Rachel E Schroeder - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA
Hanna E Stevens - Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Neuroscience letters, Vol.709, pp.134368-134368
DOI: 10.1016/j.neulet.2019.134368
PMID: 31299286
NLM abbreviation: Neurosci Lett
ISSN: 0304-3940
eISSN: 1872-7972
Publisher: Elsevier B.V
Grant note: name: Roy J. Carver Charitible Trust; name: Ida P. Haller Chair in Child Psychiatry, the University of Iowa Graduate College, Nellie Ball Trust; DOI: 10.13039/100000066, name: National Institute for Environmental Health Sciences, award: NIEHS/NIH P30 ES005605
Language: English
Date published: 09/14/2019
Academic Unit: Molecular Physiology and Biophysics; Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
Record Identifier: 9984070206802771

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