Journal article
Cellular transformation by human papillomaviruses: Lessons learned by comparing high- and low-risk viruses
Virology (New York, N.Y.), Vol.424(2), pp.77-98
03/15/2012
DOI: 10.1016/j.virol.2011.12.018
PMCID: PMC3703738
PMID: 22284986
Abstract
The oncogenic potential of papillomaviruses (PVs) has been appreciated since the 1930s yet the mechanisms of virally-mediated cellular transformation are still being revealed. Reasons for this include: a) the oncoproteins are multifunctional, b) there is an ever-growing list of cellular interacting proteins, c) more than one cellular protein may bind to a given region of the oncoprotein, and d) there is only limited information on the proteins encoded by the corresponding non-oncogenic PVs. The perspective of this review will be to contrast the activities of the viral E6 and E7 proteins encoded by the oncogenic human PVs (termed high-risk HPVs) to those encoded by their non-oncogenic counterparts (termed low-risk HPVs) in an attempt to sort out viral life cycle-related functions from oncogenic functions. The review will emphasize lessons learned from the cell culture studies of the HPVs causing mucosal/genital tract cancers.
Details
- Title: Subtitle
- Cellular transformation by human papillomaviruses: Lessons learned by comparing high- and low-risk viruses
- Creators
- Aloysius J Klingelhutz - Department of Microbiology, University of Iowa, Iowa City, IA 52242, USAAnn Roman - Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
- Resource Type
- Journal article
- Publication Details
- Virology (New York, N.Y.), Vol.424(2), pp.77-98
- DOI
- 10.1016/j.virol.2011.12.018
- PMID
- 22284986
- PMCID
- PMC3703738
- NLM abbreviation
- Virology
- ISSN
- 0042-6822
- eISSN
- 1096-0341
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 03/15/2012
- Academic Unit
- Microbiology and Immunology; Radiation Oncology
- Record Identifier
- 9984001207402771
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