Journal article
Central FGF21 production regulates memory but not peripheral metabolism
Cell reports (Cambridge), Vol.40(8), 111239
08/23/2022
DOI: 10.1016/j.celrep.2022.111239
PMCID: PMC9472585
PMID: 36001982
Abstract
Fibroblast growth factor 21 (FGF21) is a liver-derived endocrine hormone that functions to regulate energy homeostasis and macronutrient intake. Recently, FGF21 was reported to be produced and secreted from hypothalamic tanycytes, to regulate peripheral lipid metabolism; however, rigorous investigation of FGF21 expression in the brain has yet to be accomplished. Using a mouse model that drives CRE recombinase in FGF21-expressing cells, we demonstrate that FGF21 is not expressed in the hypothalamus, but instead is produced from the retrosplenial cortex (RSC), an essential brain region for spatial learning and memory. Furthermore, we find that central FGF21 produced in the RSC enhances spatial memory but does not regulate energy homeostasis or sugar intake. Finally, our data demonstrate that administration of FGF21 prolongs the duration of long-term potentiation in the hippocampus and enhances activation of hippocampal neurons. Thus, endogenous and pharmacological FGF21 appear to function in the hippocampus to enhance spatial memory.
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•FGF21 is not produced from hypothalamic tanycytes•Instead, FGF21 is expressed in the brain in the retrosplenial cortex•Brain-derived FGF21 regulates memory formation but not metabolism•FGF21 signaling to the hippocampus prolongs the duration of long-term potentiation
Zhou et al. reveal that the endocrine hormone FGF21 is expressed in the brain. Central FGF21 expression occurs in distinct areas, including the retrosplenial cortex, but not the hypothalamus. Interestingly, brain-derived FGF21 regulates spatial memory formation, but not metabolism, and the converse is true for liver-derived FGF21.
Details
- Title: Subtitle
- Central FGF21 production regulates memory but not peripheral metabolism
- Creators
- Bolu Zhou - University of IowaKristin E. Claflin - University of IowaKyle H. Flippo - University of IowaAndrew I. Sullivan - University of IowaArvand Asghari - Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, 169 Newton Road, 3322 PBDB, Iowa City, IA 52242, USASatya M. Tadinada - University of IowaSharon O. Jensen-Cody - University of IowaTed Abel - University of IowaMatthew J. Potthoff - Department of Neuroscience and Pharmacology, University of Iowa Carver College of Medicine, 169 Newton Road, 3322 PBDB, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Cell reports (Cambridge), Vol.40(8), 111239
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.celrep.2022.111239
- PMID
- 36001982
- PMCID
- PMC9472585
- ISSN
- 2211-1247
- eISSN
- 2211-1247
- Language
- English
- Date published
- 08/23/2022
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984286160202771
Metrics
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