Central Nervous System Infections Associated with Immunosuppressive Therapy for Rheumatic Disease

Michael J Bradshaw; Tracey A Cho; Felicia C Chow

doi:10.1016/j.rdc.2017.06.009

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Central Nervous System Infections Associated with Immunosuppressive Therapy for Rheumatic Disease

Journal article

Peer reviewed

Central Nervous System Infections Associated with Immunosuppressive Therapy for Rheumatic Disease

Michael J Bradshaw, Tracey A Cho and Felicia C Chow

Rheumatic diseases clinics of North America, Vol.43(4), pp.607-619

11/2017

DOI: 10.1016/j.rdc.2017.06.009

PMCID: PMC5679400

PMID: 29061246

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Abstract

Patients on immunosuppressive therapy for rheumatic diseases are at increased risk of infection. Although infections of the central nervous system (CNS) are less common compared with other sites, patients on broadly immunosuppressive and biologic immunomodulatory agents may be susceptible to more severe, disseminated forms of infection, including of the CNS. Certain key principles regarding infection risk apply across immunosuppressive therapies, including increased risk with higher doses and longer duration of therapy and with combination therapy. Providers should be aware of the CNS infection risk related to immunosuppressant use to help guide best practices for screening and prophylaxis.

Immunosuppression

Immunomodulatory therapy

Central nervous system infection

Rheumatic disease

Details

Title: Subtitle: Central Nervous System Infections Associated with Immunosuppressive Therapy for Rheumatic Disease
Creators: Michael J Bradshaw - Partners Multiple Sclerosis Center, Brigham and Women's Hospital and Massachusetts General Hospital, 60 Fenwood Road, 4th floor, Boston, MA 02115, USA
Tracey A Cho - Department of Neurology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
Felicia C Chow - Department of Neurology and Division of Infectious Diseases, University of California, San Francisco, Zuckerberg San Francisco General Hospital, 1001 Potrero Avenue, Building 1, Room 101, San Francisco, CA 94110, USA
Resource Type: Journal article
Publication Details: Rheumatic diseases clinics of North America, Vol.43(4), pp.607-619
DOI: 10.1016/j.rdc.2017.06.009
PMID: 29061246
PMCID: PMC5679400
NLM abbreviation: Rheum Dis Clin North Am
ISSN: 0889-857X
eISSN: 1558-3163
Publisher: Elsevier Inc
Grant note: KL2TR000143 / NIH/NCATS
Language: English
Date published: 11/2017
Academic Unit: Neurology; Iowa Neuroscience Institute
Record Identifier: 9984070811502771

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