Journal article
Central Vagotonic Effects of Atropine Modulate Spectral Oscillations of Sympathetic Nerve Activity
Circulation (New York, N.Y.), Vol.98(14), pp.1394-1399
10/06/1998
DOI: 10.1161/01.CIR.98.14.1394
PMID: 9760293
Abstract
Background: Low-dose atropine causes bradycardia either by acting on the sinoatrial node or by its effects on central muscarinic receptors increasing vagal activity. Any central muscarinic effects of high-dose atropine on RR interval are masked by peripheral muscarinic blockade at the sinoatrial node, which causes tachycardia. Effects of central parasympathetic activation on sympathetic activity are not known.
Methods and results: Using power spectral analysis of RR interval, intra-arterial blood pressure, respiration, and muscle sympathetic nerve activity (MSNA), we examined the effects of both low (2 microgram/kg IV) and high (15 microgram/kg IV) doses of atropine. After low-dose atropine, RR increased by 9+/-1% (P<0.0001), the low-frequency (LF) component (in normalized units, NU) of RR variability decreased by -32+/-8%, and the high-frequency (HF)NU component increased (+74+/-19%); hence, LF/HF of RR variability fell by 52+/-10% (all P<0.01). Although overall MSNA did not change, LFNU of MSNA decreased (-15+/-5%), HFNU of MSNA increased (+31+/-3%), and LF/HF of MSNA fell (-41+/-8%) (all P<0.01). After high-dose atropine, LFNU of MSNA decreased (-17+/-12%), HFNU of MSNA increased (+22+/-3%), and LF/HF of MSNA fell (-51+/-21%) (all P<0.02).
Conclusions: Increasing central parasympathetic activity with low-dose atropine is associated with an increase in the HF and a decrease in the LF oscillations of both RR interval and MSNA variability. High-dose atropine similarly induces an increase in the HF and a decrease in the LF components of MSNA variability. Thus, central parasympathetic activation is able to modulate the oscillatory characteristics of sympathetic nerve traffic to peripheral blood vessels.
Details
- Title: Subtitle
- Central Vagotonic Effects of Atropine Modulate Spectral Oscillations of Sympathetic Nerve Activity
- Creators
- Nicola Montano - From the Centro L.I.T.A. di Vialba, Centro Ricerche Cardiovascolari, CNR, Medicina Interna II, Ospedale “L. Sacco,” Università di Milano, Italy (N.M., C.C., A.P., M.P., A.M.) and the Cardiovascular Division, Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City (K.N., F.M.A., C.B., V.K.S.)Chiara Cogliati - From the Centro L.I.T.A. di Vialba, Centro Ricerche Cardiovascolari, CNR, Medicina Interna II, Ospedale “L. Sacco,” Università di Milano, Italy (N.M., C.C., A.P., M.P., A.M.) and the Cardiovascular Division, Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City (K.N., F.M.A., C.B., V.K.S.)Alberto Porta - From the Centro L.I.T.A. di Vialba, Centro Ricerche Cardiovascolari, CNR, Medicina Interna II, Ospedale “L. Sacco,” Università di Milano, Italy (N.M., C.C., A.P., M.P., A.M.) and the Cardiovascular Division, Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City (K.N., F.M.A., C.B., V.K.S.)Massimo Pagani - From the Centro L.I.T.A. di Vialba, Centro Ricerche Cardiovascolari, CNR, Medicina Interna II, Ospedale “L. Sacco,” Università di Milano, Italy (N.M., C.C., A.P., M.P., A.M.) and the Cardiovascular Division, Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City (K.N., F.M.A., C.B., V.K.S.)Alberto Malliani - From the Centro L.I.T.A. di Vialba, Centro Ricerche Cardiovascolari, CNR, Medicina Interna II, Ospedale “L. Sacco,” Università di Milano, Italy (N.M., C.C., A.P., M.P., A.M.) and the Cardiovascular Division, Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City (K.N., F.M.A., C.B., V.K.S.)Krzysztof Narkiewicz - From the Centro L.I.T.A. di Vialba, Centro Ricerche Cardiovascolari, CNR, Medicina Interna II, Ospedale “L. Sacco,” Università di Milano, Italy (N.M., C.C., A.P., M.P., A.M.) and the Cardiovascular Division, Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City (K.N., F.M.A., C.B., V.K.S.)Francois M Abboud - From the Centro L.I.T.A. di Vialba, Centro Ricerche Cardiovascolari, CNR, Medicina Interna II, Ospedale “L. Sacco,” Università di Milano, Italy (N.M., C.C., A.P., M.P., A.M.) and the Cardiovascular Division, Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City (K.N., F.M.A., C.B., V.K.S.)Clay Birkett - From the Centro L.I.T.A. di Vialba, Centro Ricerche Cardiovascolari, CNR, Medicina Interna II, Ospedale “L. Sacco,” Università di Milano, Italy (N.M., C.C., A.P., M.P., A.M.) and the Cardiovascular Division, Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City (K.N., F.M.A., C.B., V.K.S.)Virend K Somers - From the Centro L.I.T.A. di Vialba, Centro Ricerche Cardiovascolari, CNR, Medicina Interna II, Ospedale “L. Sacco,” Università di Milano, Italy (N.M., C.C., A.P., M.P., A.M.) and the Cardiovascular Division, Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City (K.N., F.M.A., C.B., V.K.S.)
- Resource Type
- Journal article
- Publication Details
- Circulation (New York, N.Y.), Vol.98(14), pp.1394-1399
- DOI
- 10.1161/01.CIR.98.14.1394
- PMID
- 9760293
- NLM abbreviation
- Circulation
- ISSN
- 0009-7322
- eISSN
- 1524-4539
- Publisher
- Lippincott Williams & Wilkins
- Language
- English
- Date published
- 10/06/1998
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984025666002771
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