Central endogenous angiotensin-(1–7) protects against aldosterone/NaCl-induced hypertension in female rats

Baojian Xue; Zhongming Zhang; Ralph F Johnson; Fang Guo; Meredith Hay; Alan Kim Johnson

doi:10.1152/ajpheart.00193.2013

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Central endogenous angiotensin-(1–7) protects against aldosterone/NaCl-induced hypertension in female rats

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Central endogenous angiotensin-(1–7) protects against aldosterone/NaCl-induced hypertension in female rats

Baojian Xue, Zhongming Zhang, Ralph F Johnson, Fang Guo, Meredith Hay and Alan Kim Johnson

American journal of physiology. Heart and circulatory physiology, Vol.305(5), pp.H699-H705

09/01/2013

DOI: 10.1152/ajpheart.00193.2013

PMCID: PMC3761325

PMID: 23812385

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Abstract

In comparison to male rodents, females are protected against angiotensin (ANG) II- and aldosterone (Aldo)-induced hypertension. However, the mechanisms underlying this protective effect are not well understood. ANG-(1–7) is formed from ANG II by angiotensin-converting enzyme 2 (ACE2) and has an antihypertensive effect in the central nervous system (CNS). The present study tested the hypothesis that central ANG-(1–7) plays an important protective role in attenuating the development of Aldo/NaCl-hypertension in female rats. Systemic infusion of Aldo into intact female rats with 1% NaCl as their sole drinking fluid resulted in a slight increase in blood pressure (BP). Intracerebroventricular (icv) infusion of A-779, an ANG-(1–7) receptor (Mas-R) antagonist, significantly augmented the pressor effects of Aldo/NaCl. In contrast, systemic Aldo/NaCl induced a significant increase in BP in ovariectomized (OVX) female rats, and central infusion of ANG-(1–7) significantly attenuated this Aldo/NaCl pressor effect. The inhibitory effect of ANG-(1–7) on the Aldo/NaCl pressor effect was abolished by concurrent infusion of A-779. RT-PCR analyses showed that there was a corresponding change in mRNA expression of several renin-angiotensin system components, estrogen receptors and an NADPH oxidase subunit in the lamina terminalis. Taken together these results suggest that female sex hormones regulate an antihypertensive axis of the brain renin-angiotensin system involving ACE2/ANG-(1–7)/Mas-R that plays an important counterregulatory role in protecting against the development of Aldo/NaCl-induced hypertension.

aldosterone

angiotensin-(1–7)

blood pressure

Cardiovascular Neurohormonal Regulation

central nervous system

Details

Title: Subtitle: Central endogenous angiotensin-(1–7) protects against aldosterone/NaCl-induced hypertension in female rats
Creators: Baojian Xue - Department of Psychology, University of Iowa, Iowa City, Iowa
Zhongming Zhang - Department of Psychology, University of Iowa, Iowa City, Iowa
Ralph F Johnson - Department of Psychology, University of Iowa, Iowa City, Iowa
Fang Guo - Department of Psychology, University of Iowa, Iowa City, Iowa
Meredith Hay - Department of Physiology, University of Arizona, Tucson, Arizona; and Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, Arizona
Alan Kim Johnson - Department of Psychology, University of Iowa, Iowa City, Iowa; Department of Pharmacology, University of Iowa, Iowa City, Iowa; the Cardiovascular Center, University of Iowa, Iowa City, Iowa
Resource Type: Journal article
Publication Details: American journal of physiology. Heart and circulatory physiology, Vol.305(5), pp.H699-H705
DOI: 10.1152/ajpheart.00193.2013
PMID: 23812385
PMCID: PMC3761325
NLM abbreviation: Am J Physiol Heart Circ Physiol
ISSN: 0363-6135
eISSN: 1522-1539
Publisher: American Physiological Society
Language: English
Date published: 09/01/2013
Academic Unit: Psychological and Brain Sciences; Neuroscience and Pharmacology; Neurology (Pediatrics); Health, Sport, and Human Physiology
Record Identifier: 9984213265302771

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