Central mechanisms in the maintenance of chronic widespread noninflammatory muscle pain

Josimari M DeSantana; Kathleen A Sluka

doi:10.1007/s11916-008-0057-7

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Central mechanisms in the maintenance of chronic widespread noninflammatory muscle pain

Journal article

Open access

Peer reviewed

Central mechanisms in the maintenance of chronic widespread noninflammatory muscle pain

Josimari M DeSantana and Kathleen A Sluka

Current pain and headache reports, Vol.12(5), pp.338-343

10/2008

DOI: 10.1007/s11916-008-0057-7

PMCID: PMC2744440

PMID: 18765138

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https://www.ncbi.nlm.nih.gov/pmc/articles/2744440View

Open Access

Abstract

Chronic widespread pain (CWP) conditions such as fibromyalgia and myofascial syndromes are characterized by generalized pain, tenderness, morning stiffness, disturbed sleep, and pronounced fatigue. However, CWP pathophysiology is still unclear. A number of hypotheses have been proposed as the underlying pathophysiology of CWP: muscular dysfunction/ischemia, central sensitization, and a deficit in endogenous pain-modulating systems. This article reviews the current and emerging literature about the pathophysiology and neurobiology of chronic widespread -musculoskeletal pain. Widespread musculoskeletal pain results in changes in the central nervous system in human subjects and animal models. These changes likely reflect alterations in supraspinal modulation of nociception, and include increases in excitatory and decreases in inhibitory modulation pathways. These alterations in excitation and inhibition likely drive changes observed in the spinal cord to result in central sensitization, and the consequent pain and hyperalgesia.

Fibromyalgia - therapy

Fibromyalgia - metabolism

Synaptic Transmission - physiology

Humans

Nociceptors - physiology

Amides - therapeutic use

Ropivacaine

Nerve Block - methods

Cyclic AMP - physiology

Fatigue - epidemiology

Aspartic Acid - metabolism

Myofascial Pain Syndromes - physiopathology

Signal Transduction - physiology

Anesthetics, Local - therapeutic use

Glutamic Acid - metabolism

Fibromyalgia - physiopathology

Myofascial Pain Syndromes - metabolism

Chronic Disease

Myofascial Pain Syndromes - therapy

Details

Title: Subtitle: Central mechanisms in the maintenance of chronic widespread noninflammatory muscle pain
Creators: Josimari M DeSantana - Physical Therapy and Rehabilitation Science, 1-242 MEB, University of Iowa, Iowa City, IA 52252, USA
Kathleen A Sluka
Resource Type: Journal article
Publication Details: Current pain and headache reports, Vol.12(5), pp.338-343
DOI: 10.1007/s11916-008-0057-7
PMID: 18765138
PMCID: PMC2744440
NLM abbreviation: Curr Pain Headache Rep
ISSN: 1531-3433
eISSN: 1534-3081
Publisher: United States
Grant note: R01 AR052316-03 / NIAMS NIH HHS R01 AR052316 / NIAMS NIH HHS R01 AR052316-04 / NIAMS NIH HHS R01 AR052316-01A1 / NIAMS NIH HHS R01 AR052316-02 / NIAMS NIH HHS
Language: English
Date published: 10/2008
Academic Unit: Iowa Neuroscience Institute; Nursing; Physical Therapy and Rehabilitation Science; Neuroscience and Pharmacology
Record Identifier: 9984040449402771

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