Journal article
Central mineralocorticoid receptor blockade improves volume regulation and reduces sympathetic drive in heart failure
American journal of physiology. Heart and circulatory physiology, Vol.281(5), pp.H2241-H2251
11/01/2001
DOI: 10.1152/ajpheart.2001.281.5.H2241
PMID: 11668089
Abstract
The mineralocorticoid (MC) receptor antagonist spironolactone (SL) improves morbidity and mortality in patients with congestive heart failure (CHF). We tested the hypothesis that the central nervous system actions of SL contribute to its beneficial effects. SL (100 ng/h for 28 days) or ethanol vehicle (VEH) was administered intracerebroventricularly or intraperitoneally to rats with CHF induced by coronary artery ligation (CL) and to SHAM-operated controls. The intracerebroventricular SL treatment prevented the increase in sodium appetite and the decreases in sodium and water excretion observed within a week of CL in VEH-treated CHF rats. Intraperitoneal SL also improved volume regulation in the CHF rats, but only after 3 wk of treatment. Four weeks of SL treatment, either intracerebroventricularly or intraperitoneally, ameliorated both the increase in sympathetic drive and the impaired baroreflex function observed in VEH-treated CHF rats. These findings suggest that activation of MC receptors in the central nervous system plays a critical role in the altered volume regulation and augmented sympathetic drive that characterize clinical heart failure.
Details
- Title: Subtitle
- Central mineralocorticoid receptor blockade improves volume regulation and reduces sympathetic drive in heart failure
- Creators
- Joseph Francis - Research Service, Department of Veterans Affairs Medical Center, and Departments of, Internal Medicine andRobert M Weiss - Research Service, Department of Veterans Affairs Medical Center, and Departments of, Internal Medicine andShun-Guang Wei - Research Service, Department of Veterans Affairs Medical Center, and Departments of, Internal Medicine andAlan Kim Johnson - Psychology, University of Iowa, Iowa City, Iowa 52242Terry G Beltz - Psychology, University of Iowa, Iowa City, Iowa 52242Kathy Zimmerman - Research Service, Department of Veterans Affairs Medical Center, and Departments ofRobert B Felder - Research Service, Department of Veterans Affairs Medical Center, and Departments of, Internal Medicine and
- Resource Type
- Journal article
- Publication Details
- American journal of physiology. Heart and circulatory physiology, Vol.281(5), pp.H2241-H2251
- DOI
- 10.1152/ajpheart.2001.281.5.H2241
- PMID
- 11668089
- ISSN
- 0363-6135
- eISSN
- 1522-1539
- Language
- English
- Date published
- 11/01/2001
- Academic Unit
- Psychological and Brain Sciences; Iowa Neuroscience Institute; Cardiovascular Medicine; Neuroscience and Pharmacology; Health and Human Physiology; Internal Medicine
- Record Identifier
- 9984065475902771
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