Journal article
Central nicotine induces browning through hypothalamic κ opioid receptor
Nature communications, Vol.10(1), pp.4037-12
09/06/2019
DOI: 10.1038/s41467-019-12004-z
PMCID: PMC6731305
PMID: 31492869
Abstract
Increased body weight is a major factor that interferes with smoking cessation. Nicotine, the main bioactive compound in tobacco, has been demonstrated to have an impact on energy balance, since it affects both feeding and energy expenditure at the central level. Among the central actions of nicotine on body weight, much attention has been focused on its effect on brown adipose tissue (BAT) thermogenesis, though its effect on browning of white adipose tissue (WAT) is unclear. Here, we show that nicotine induces the browning of WAT through a central mechanism and that this effect is dependent on the κ opioid receptor (KOR), specifically in the lateral hypothalamic area (LHA). Consistent with these findings, smokers show higher levels of uncoupling protein 1 (UCP1) expression in WAT, which correlates with smoking status. These data demonstrate that central nicotine-induced modulation of WAT browning may be a target against human obesity.
Details
- Title: Subtitle
- Central nicotine induces browning through hypothalamic κ opioid receptor
- Creators
- Patricia Seoane-Collazo - CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), 28029, Santiago de Compostela, SpainLaura Liñares-Pose - CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), 28029, Santiago de Compostela, SpainEva Rial-Pensado - CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), 28029, Santiago de Compostela, SpainAmparo Romero-Picó - CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), 28029, Santiago de Compostela, SpainJosé María Moreno-Navarrete - Department of Diabetes, Endocrinology and Nutrition, Hospital de Girona Dr Josep Trueta, Institut D'investigació Biomèdica de Girona (IdIBGi) and University of Girona, 17007, Girona, SpainNoelia Martínez-Sánchez - Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UKPablo Garrido-Gil - CIBER Enfermedades Neurodegenerativas (CIBERNED), 28029, Santiago de Compostela, SpainRamón Iglesias-Rey - Clinical Neurosciences Research Laboratory, Instituto de Investigación Sanitaria, 15782, Santiago de Compostela, SpainDonald A Morgan - Department of Pharmacology, University of Iowa, Iowa City, IA, 52242, USANaoki Tomasini - Obesity Laboratory, Instituto Gulbenkian de Ciência, 2780-156, Oeiras, PortugalSamuel Andrew Malone - Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UKAna Senra - CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), 28029, Santiago de Compostela, SpainCintia Folgueira - CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), 28029, Santiago de Compostela, SpainGema Medina-Gomez - Department of Basic Sciences of Health, Area of Biochemistry and Molecular Biology, Universidad Rey Juan Carlos, 28922, Alcorcon-Madrid, SpainTomás Sobrino - Clinical Neurosciences Research Laboratory, Instituto de Investigación Sanitaria, 15782, Santiago de Compostela, SpainJosé L Labandeira-García - CIBER Enfermedades Neurodegenerativas (CIBERNED), 28029, Santiago de Compostela, SpainRubén Nogueiras - CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), 28029, Santiago de Compostela, SpainAna I Domingos - Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UKJosé-Manuel Fernández-Real - Department of Diabetes, Endocrinology and Nutrition, Hospital de Girona Dr Josep Trueta, Institut D'investigació Biomèdica de Girona (IdIBGi) and University of Girona, 17007, Girona, SpainKamal Rahmouni - Department of Internal Medicine, University of Iowa, Iowa City, IA, 52242, USACarlos Diéguez - CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), 28029, Santiago de Compostela, Spain. carlos.dieguez@usc.esMiguel López - CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), 28029, Santiago de Compostela, Spain. m.lopez@usc.es
- Resource Type
- Journal article
- Publication Details
- Nature communications, Vol.10(1), pp.4037-12
- DOI
- 10.1038/s41467-019-12004-z
- PMID
- 31492869
- PMCID
- PMC6731305
- NLM abbreviation
- Nat Commun
- ISSN
- 2041-1723
- eISSN
- 2041-1723
- Publisher
- England
- Grant note
- P01 HL084207 / NHLBI NIH HHS I01 BX004249 / BLRD VA 208576/Z/17/Z / Wellcome Trust
- Language
- English
- Date published
- 09/06/2019
- Academic Unit
- Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984070614202771
Metrics
14 Record Views