Central, peripheral and resistance arterial reactivity: fluctuates during the phases of the menstrual cycle

Eric J Adkisson; Darren P Casey; Darren T Beck; Alvaro N Gurovich; Jeffery S Martin; Randy W Braith

doi:10.1258/ebm.2009.009186

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Central, peripheral and resistance arterial reactivity: fluctuates during the phases of the menstrual cycle

Journal article

Open access

Peer reviewed

Central, peripheral and resistance arterial reactivity: fluctuates during the phases of the menstrual cycle

Eric J Adkisson, Darren P Casey, Darren T Beck, Alvaro N Gurovich, Jeffery S Martin and Randy W Braith

Experimental biology and medicine (Maywood, N.J.), Vol.235(1), pp.111-118

01/2010

DOI: 10.1258/ebm.2009.009186

PMCID: PMC2967291

PMID: 20404025

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Abstract

The purpose of this study was to document the temporal changes in vascular reactivity occurring simultaneously in central, peripheral and microvascular resistance arteries in the same cohort of women during the normal menstrual cycle. Twenty-three (n = 23) women (mean age (+/-SD) = 19 +/- 1 y) were tested during four phases of a normal menstrual cycle. Delineation of the four phases occurred as follows: (1) the early follicular phase; (2) the late follicular (LF) phase; (3) the early luteal (EL) phase; and (4) the late luteal phase. Non-invasive measurement of central hemodynamics and peripheral artery pulse wave velocity (PWV) were performed using applanation tonometry. Measurement of peripheral endothelial function was determined by flow-mediated dilation (FMD) testing in the brachial artery and venous occlusion plethysmography in the forearm and calf resistance arteries. Additionally, plasma NOx and 17beta-estradiol (E) concentrations were measured. Both central (aortic) and peripheral blood pressure (BP) were lowest (P < 0.05) during the LF phase and BP reduction was sustained (P < 0.05) into the EL phase. The timing and amplitude of the reflected pressure wave were attenuated only during the LF phase (P < 0.05). No temporal changes were observed in either central (carotid-femoral) or peripheral PWV (femoral-dorsalis pedis, carotid-radial). Peak forearm and calf blood flow during reactive hyperemia were greatest in LF. Brachial FMD was greatest during the LF phase (P < 0.05). Plasma E and NOx concentrations were highest during the LF phase (P < 0.05). Young premenopausal women experienced an overwhelming pattern of reduced BP and increased systemic vascular reactivity during the LF phase prior to ovulation.

Blood Pressure

Estradiol - blood

Nitric Oxide - blood

Menstrual Cycle - blood

Humans

Luteal Phase - blood

Follicular Phase - physiology

Vascular Resistance - physiology

Endothelium, Vascular - physiology

Follicular Phase - blood

Young Adult

Arteries - physiology

Luteal Phase - physiology

Adolescent

Blood Flow Velocity

Female

Menstrual Cycle - physiology

Brachial Artery - physiology

Cohort Studies

Details

Title: Subtitle: Central, peripheral and resistance arterial reactivity: fluctuates during the phases of the menstrual cycle
Creators: Eric J Adkisson - Department of Applied Physiology and Kinesiology, Center for Exercise Science, College of Health and Human Performance, University of Florida, Gainesville, FL 32611, USA
Darren P Casey
Darren T Beck
Alvaro N Gurovich
Jeffery S Martin
Randy W Braith
Resource Type: Journal article
Publication Details: Experimental biology and medicine (Maywood, N.J.), Vol.235(1), pp.111-118
DOI: 10.1258/ebm.2009.009186
PMID: 20404025
PMCID: PMC2967291
NLM abbreviation: Exp Biol Med (Maywood)
ISSN: 1535-3702
eISSN: 1535-3699
Publisher: England
Grant note: P30 AG028740 / NIA NIH HHS T32 HL083810 / NHLBI NIH HHS T32 HL083810-05 / NHLBI NIH HHS
Language: English
Date published: 01/2010
Academic Unit: Physical Therapy and Rehabilitation Science; Fraternal Order of Eagles Diabetes Research Center
Record Identifier: 9984047987002771

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